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Database: UniProt
Entry: K1QEZ9_CRAGI
LinkDB: K1QEZ9_CRAGI
Original site: K1QEZ9_CRAGI 
ID   K1QEZ9_CRAGI            Unreviewed;       335 AA.
AC   K1QEZ9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   13-SEP-2023, entry version 36.
DE   SubName: Full=Short chain dehydrogenase/reductase family 42E member 1 {ECO:0000313|EMBL:EKC29679.1};
GN   ORFNames=CGI_10026065 {ECO:0000313|EMBL:EKC29679.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC29679.1};
RN   [1] {ECO:0000313|EMBL:EKC29679.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC29679.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR   EMBL; JH817657; EKC29679.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1QEZ9; -.
DR   HOGENOM; CLU_007383_6_8_1; -.
DR   InParanoid; K1QEZ9; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; EPIMERASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01073; 3Beta_HSD; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|RuleBase:RU004475};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane {ECO:0000256|RuleBase:RU004475};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU004475}.
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   TRANSMEM        305..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU004475"
FT   DOMAIN          12..85
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   DOMAIN          86..214
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   335 AA;  37650 MW;  33F1DE6AEF4245D5 CRC64;
     MSADDFADDV HLVTGGAGFT GFKLGQKLAD IGKKVILVDI VPPKWPLAGN MTFVQCNLTK
     EQEVTSALRG ANCVYHLASY GMSGKEHFLD HYSKTKRIAE QKVLEADKEN VLRTCALRLG
     GVYGVGEQRH TPRVVNMTKN GLMVALFGTE SMTDFLHVDN MVQAHILAAK ALTKAEGCKA
     AGQAYFISDG APINTFDFFR PLIKGLGYPM PTIPIPVWLM WFIALVLECV HFIVSGIYDF
     QPIFTRMEVL KMCVNNYFCI DKAKRELGYM PVKQNYLSDV LDDFIKQGFR KKETMKKPVV
     ISMRWCVNIA LSVIFTSFVL SYLQTLNFIH LEKLH
//
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