ID K1QI76_CRAGI Unreviewed; 2740 AA.
AC K1QI76;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Gem-associated protein 5 {ECO:0000313|EMBL:EKC33488.1};
GN ORFNames=CGI_10012186 {ECO:0000313|EMBL:EKC33488.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC33488.1};
RN [1] {ECO:0000313|EMBL:EKC33488.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC33488.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SIMILARITY: Belongs to the TMEM131 family.
CC {ECO:0000256|ARBA:ARBA00006682}.
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DR EMBL; JH816294; EKC33488.1; -; Genomic_DNA.
DR HOGENOM; CLU_227108_0_0_1; -.
DR InParanoid; K1QI76; -.
DR OMA; NWEPVLY; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR039877; TMEM131-like.
DR InterPro; IPR045695; TMEM131-like_conserved.
DR InterPro; IPR022113; TMEM131-like_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22050; RW1 PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR22050:SF0; TRANSMEMBRANE PROTEIN 131 HOMOLOG; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF19532; TMEM131_like; 1.
DR Pfam; PF12371; TMEM131_like_N; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00060; FN3; 2.
DR SMART; SM00320; WD40; 11.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2515..2619
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2623..2718
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 2740 AA; 305775 MW; F6CE2D230A5CCBB6 CRC64;
MARVKCHDRR KMSGECLHFL LLIQSFTQCF LHTLAVESHS QAFVQTDNHL TYIGDGRDIN
GIPLEVNPGH TYTSAENIIY KNSVRLDPPW LDFQERPVGM PFLEQVVVHN TDSRNDLHLL
SISGSTVHFH CSFFQEKVVP PGGNTTFDVV FLAREEGNVE NTLYIHTSVG SFSYNVFGVG
IPNPYRLRPY LGAKVPLNSS FTPIIKIHNP FSSTLQVTEM FSSEGDLHLE LPSGDIEAPR
SLWEIPPYET KTVMKANFVG RVENNHTAFI RIKTNQEQMN NVVILPVEVE VSSVPGLYSP
AEMIDFGIIR TLDDPVTVSL NLVNTGYKPV HISILLQIQN FTVPFTLKPR RTSTPFYLQF
HPNETQLHFT TYLTLHTNAS TFTIPIVVYN GLLKVIPHRP EKFKGQFDFG TMGVKEKRSM
IFTLRNDNPI DVHIGEVTPD MNGTKVFFLG MEKGNGTMLT QKHNITEVDY NFLKIKPYHF
AVFRLNLTAP DHEGMFASDM LITTQFEDIW IPIAVRTADG SLIAIPESLH FDKMYPGMVD
FRVLQIHSTF RDKMEVIGVT FQPPDSRFYY QPPNTDKILL FPDKHTNVGK IYFDAKRECK
DDCYVGLATN TPAGQQWLIG LALFQDAVET DRYLYSKLQQ KWRTIHRSSL NTANVTIEMD
TDEVRGFLYS AQAHLHWPSL VRKCHIKFPL TQIGNISISD FIVENPGDIP VLIQILPLPL
YPNPQIITDL LYRKFSTDPG DTIEMDDMDI FTLPDLEQYN PSRQNPVPGF RRHIETSLGV
KPHKQSIATI LQPGVKVKVR VGFQPRDDIS RTSIILIRNN LTIIDAIVVQ GQGGRGEMKL
SNKRPGSAIP LQFDITEKHL KNCDKKKQAK NTMVPNFTVR RSFTLKNTGE LPFFIHSYSI
NGSPCEGYGF RVLDCEGYEM LPNTSRKIDI AFTPDFTMSR IRRILTIHSS LGPVANYTLQ
ATIPPHTLSR CSSALPRPNW EPVLYYSITC VMAFLLFCIL VAAYFEADRI FVADIIRRKI
KYSNATQTFD KSKIFDLKQV AGITSTQTPS LPTKVTQVPP SLSQNNNVTT KAVINLSNGH
VEHRSQKESF GSTLLKIFKR LFASKPSRSS NNKKSKVEKA EPVKEEPVQS QQVPKNKSAD
ERVSANQESE KSNITQKTRN KKAARRQHST EFVASQGEGY NGGHPETKQN DTSLSQYSRQ
TSSETSDKVY KNSHKTTTSS GLDDLILLED AKSEMNEAKM KNRKKNRNRP ELPRYMTQAS
VDDETSSTST ESSVGEIEEK SSSARDSTPE PQHQPKPKKS KPRVVKTTGH YDSTIDDADF
ELTSKSKGHK RIKSKSKDVY GGDIFHPDSL ELPYDMEKLE KKEKSKKKAL KLQSLKGDSE
SSDSRGSQDE PIPNWDMPVN SPDEDLSELA QQTARFAQKH GKNITPNGTG PDLLSGSSRS
SSYSDIVNSN ENGKSKEPRR SHTFPGVTPE NLPGAIGTKA RAAPVGSGKG RNVWNATPPT
TPDSVLGSFG LQTIQETNRV STSETILPTS TPSSPHVAPD VPADPFAPAD GPFSGNFMNY
TSAPSYEAPQ TMMQRLQQER RTRLQEHRRR VMQGEEWPGF DVPPVGSESL WDNEYNPMSA
KWPAGPDTPA SLQGPNSLWS TLTNSANNSW NSLMSFTSGW GGPQASTGAE TTTTDSAPPR
TLQEMDAGQA FNPFNTMSDI WGPNAPTTTS GWNIPPKTEE QMCDLILPPS PQWYCSKIID
FNTKGVVVFG ARHDVFVLDA SIIPPIYKAQ CCLHKERISS LALNESNVCC SASEDGKVKV
WSIDNPMEAI ADHNTHRGKI SCITWSSENS DVVVSGDDGG QIIGWQYHEN RTVCYCPESA
PIVYLACSNL IETQVAIGYK TGVILIIEMK DWREGRVLQR LRGHDEDVLC VAWCPVPGEN
FKTYQDLDNP NSQSPNAEAD AVTPMDFGSE GHLLASSSKD KTVRIWSSLR GRQIAVFKSP
KSNQFAREDK TKSWSTLLWN PNNANHVYVS SSGGEILKWN LDSGPSQKPA SISSAKVLSH
NRPVFCMCAG GLNNSLMCTV SMDRQMIFWN LPQCVPVCAV PTLGGFVYAV KTSPIDPGRL
AIGVGDSMIR LWNMNNSVNP FDVTVLWQGI KSKVTALAWH PVKEGRLGFG TDDGRVGVFD
TLSNKPPSIS SHYHRRTVYV VAWGPACSTV SEEENETLFV IYSVGDGIIL SHDPKKFQNE
AQDINSVIFK MNGPKQRVPI RSEVSWNPDF SLVAIGNDDG SVEIYKSGSF KLLCVVHIHR
KLVNSIQWHP IHNVETSSSQ KYYIATGSNE ATIQIVDLSS VLGDEVVLIS EAKTTLFGHN
NRIVGLQWSP HDDNTLASVS FDGTARVWDA SKGQTIASYH GHRGRLLCVQ WSGSDPDVVF
TGGEDFTFHK WRVSRNPYSA EDDAQRKKKT KSRGRKKTLK DADDKNTSRE VKGSKTDHPE
EDKGSTQHNE VKVTEPSVTL DTRTQASLDE LLLKKKAELE GTEYMPSEDI EALQVPRETT
IEKQQQNAAI VQPSKNLMDT DSSTKSNENK IDANGLITKY RLSVEEEMKS YQIEIDTDVT
SVITKDLSAY TSYHVKVKAT TSIGWGTFSN VRTVRTLEDV SGSPENFSVI FQDETTIGLQ
WTSPSFTTGV IHGYKLSYHR GTEDSERIVI YRSHSTLSQV NVTDLDSGEY HHFRVQTRSG
AGYGPSVNQS SFTLLARPVK PAVPIISYSN LGLSLQVYCS
//
