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Database: UniProt
Entry: K1QQ46_CRAGI
LinkDB: K1QQ46_CRAGI
Original site: K1QQ46_CRAGI 
ID   K1QQ46_CRAGI            Unreviewed;      2792 AA.
AC   K1QQ46;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|EMBL:EKC35963.1};
GN   ORFNames=CGI_10027521 {ECO:0000313|EMBL:EKC35963.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Pteriomorphia;
OC   Ostreoida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC35963.1, ECO:0000313|Proteomes:UP000005408};
RN   [1] {ECO:0000313|EMBL:EKC35963.1, ECO:0000313|Proteomes:UP000005408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC35963.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W.H., Paps J.,
RA   Zhu Y., Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J.,
RA   Wen B., Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D.,
RA   Xu Z., Liu Y., Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B.,
RA   Cheng P., Jiang X., Li J., Fan D., Wang W., Fu W., Wang T., Wang B.,
RA   Zhang J., Peng Z., Li Y., Li N., Wang J., Chen M., He Y., Tan F.,
RA   Song X., Zheng Q., Huang R., Yang H., Du X., Chen L., Yang M.,
RA   Gaffney P.M., Wang S., Luo L., She Z., Ming Y., Huang W., Zhang S.,
RA   Huang B., Zhang Y., Qu T., Ni P., Miao G., Wang J., Wang Q.,
RA   Steinberg C.E.W., Wang H., Li N., Qian L., Zhang G., Li Y., Yang H.,
RA   Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
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DR   EMBL; JH816729; EKC35963.1; -; Genomic_DNA.
DR   EnsemblMetazoa; EKC35963; EKC35963; CGI_10027521.
DR   InParanoid; K1QQ46; -.
DR   OMA; HITICRE; -.
DR   OrthoDB; EOG091G00MQ; -.
DR   Proteomes; UP000005408; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 2.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005408};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:EKC35963.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005408};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2198   2220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2263   2285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2340   2366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2386   2408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2458   2485       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      219    273       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    404       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      442    514       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2792 AA;  320312 MW;  239AE3E5EE9F2D9C CRC64;
     MDLPLEIRVH DENGDSCLDS DDDLVGCEVH GQLKLYHKML RQLHTELHGC GEEPGMGEYL
     CIGDYVCLYC EETEGYIYSS QSRMENGGVF SGGKTMTWWK CQGRSTVVRD EFSVYTGLRM
     AMGDSTSHCS NALFSSNNGL FIYSNQERNR PRNIPNPQVV VFQVCIQNRY KLNKKYRKWM
     NSIQTDNTEQ VTRGLLKQAK SAADAENKDN EAEQTRQHGK RVRYGEVVQL KHVFTGKFVH
     MSTTQTSQKD KNNMKVSLHE YNAKNAQFRI LPRYKVKSEG EIVQLFDQIV FESVKSHGHY
     FHASEPFQID HFSYGSELNL GVERSSFTLI GSYRALQEQD RFVRGGSVIR LFHKELEAYL
     VAEGLFEDCV TEDVHFRIRV IDQHKPRSLS PSTSGITYWQ IEAEHSILDG DILRWEQQVR
     LRHFLTRQYL CIDSKMDVSL ERDEISYESY ARIEHMLTGC WLHALKDEDY ERKVDDGGVK
     ERSMQGLRWD SAGVRKVSAS SESMYDDAYT LQHVLPEDVH NFNYVAGMVP FLFNLIQDLQ
     MEPELNAKKT HGIITALKEI KLFMLPLCQP DKNRQKLMRN LRVIDLLVNL LQCPLGDGEE
     ESHVIRIFKE AYDVLHAYMI GKSRKNALYM AKYIDFFQTQ FTQKGGIGLN VAQMIVELIR
     DKRKIVDRIT KNNIDTFLQL LRTNQNYRFL DLLQVLCVCD GVAIPNNQTY IVDQWLRESR
     DSVYLTERGQ NINKRPNIVY VSTDQGRTWV PLHLFVDFES TEFDEEKYNF LIHQLDLFKA
     LCFGRNDYAV HVITREFGYL TWEDAYLCLT ADLLPDHIRA KYCELIIGLF VDVGNNYSVL
     DHPNICFIYE YVGSKDSERE QSSFVLRLLQ HLVKFGYYMD MEDVKQLLTP LLSLLDGTHD
     VPFPKDKGKG YSKDSQKTVN QYRSTGRFEQ SKEAEAVVNA KYQAMEVLDF LLTFQRNLRL
     KAFVSKFKVC EQNASRHRSP VVMESLMYEV YNPQEQTKKA LKCQKKVLKE IREMVSLSSI
     FDMDNTTRVL LDLSEYKYDR VVTKSLDILN KLYSSQEDMF KLADRAQILL THDSARVHRE
     VQRSLPVLRR LAKQKLNDQQ VQLMSEILDE LAEYGVPGIL HIVVDILSQE IDAKLVEQQY
     MGMATIFKKT LYLMELLARE NSAVQETLFE HIDDLLEVQI VPSNLAIALK EFFFANQTTC
     LKVSSKQIQK IVLLCAHHQN EAPEFLELLS VLVKVEGLDM TIKRNQALVM KYIMQNYRKA
     AYVLDQPRDQ RELILTNQGQ EGDLTYYIDL VDLLATCAEG ENKFIESLCQ TILPMQDIFW
     VINHPNIACN LKKPFVKYLM WVYMKPVGSM TESGVADLQH NRDLWEFIEA AGNVINQVTN
     AIKTQGEKIA TILKAPPSKS FIDDPHDPRS VIHGGVFFIL DAALPFFEVF FSLFYAPDKD
     LYPHEAVVTE DLATGLTGFT DVIGHLLTNP AHMKSVVSLL TILISTSSSP KAALISVLEK
     FSTEMKLGDT KTAVRKGNME YYASELELNA KFHTFATNSS VLFRGHNTVQ AQMKYKNKRD
     YTAMGSNEEL PLGEEFQSLL KCFVDHHEKK AMKRFAPAKK LLQQLDISAK VVRKGNAITN
     TSQEDLDIKC LQLLRAMVHN EERKLPDDWD TKTAEHKIKT QLGHIKDVQN AINTHDFVNK
     VLPHIARRSD SICREVLAFL SIMLFNANRE VQRSMLDYFL STREEVFFMA VRERMQISTN
     SIKEKRSLLV QHQGRVKEAL DNLSSFQTSI SAGRRALQAA LSRAKAPVIE SKRDKKKRMK
     DQKKKNMVIS NGIKRDHSSN EALLKYSDPS PDTLQNPVTL MVPDSEPTVV VAVEEDEEKA
     AEEMIATMNE GVVDMLEYKD DGYIELIFKL LARICDGQHF GLQNYLREQP DNVKSFNIVG
     ETAQFLNVVY TTINKKTINL IIQLFNTLNE FCSGNQENRV VVYDRKLVDY INFILRAGDI
     ADCAPEKILE LRQAIASVII SLIEENGPGK SQVAKEVKDT LDKGAIFRCM TLCYEAHQSE
     KPSLEELSPT EEGSVLKSAR SLAVVGGSIL QGFVKNQLRE TLMEVGFTFF LILARMQDID
     PLMSTTLQIT PDQAKAYEFY KKNSLSIELI KDDVLQKVNF RNFLREEVKE NLKWNVDRSS
     PSNKIRDLMG WTRDIMQDIS YQRKILCNPI AMMFTKGWLL WNHGATILSL AINLFMLVTW
     NAKASREDFD KHNQSITNQT LDRALLQDPI PRIGYVPHDH YTLAMYALGG THNLLSLFVL
     ISYFLSNHPR FPTKEEVKAP FRALCGGGNN GSGKKKSDDL TEKKPDEISK LDVKFFSFTT
     FYYTMFLAMS AAGTKFHGYF FAFHLLNIVN NNQLLSGVIK AVTLNGVSLL WVAILGLIVI
     YIYALVGFSL LRAYFSPGEY LYCSTLWQCT VTVIRYGLIG DMFDNIKQNG VNDSFETFWP
     LVLYHVSFFI FITTIGLNII FGIIVDTFSE LRDLKWRAES DMKDTCFICS RNSYDFEHNG
     KGFDHHVRNE HNMWAYVFFL IHLEDVKTSD FTALELYVHK LVALENYDFF PMNRALCLTS
     VDTDSTESKI DELLNRVTSI ALKQKEEETE KKRKAEKMKQ KRWQEKHRQF MFGIQDDDGN
     GNDNTKSQSS DKIVVKSKSD RSLSRPPSIV SLQKTPTTPD GTLDRRDTKK DAIEQKAKLV
     LRESDESEVA ATEDSDSVGS INEEYDLLKE DFSTAGMLDP MPPAFRERAL SIPGISSLVQ
     QTGEEERKSG DELRVLVEDE TDDESGREST RL
//
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