ID K1QS48_CRAGI Unreviewed; 1057 AA.
AC K1QS48;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=CGI_10027028 {ECO:0000313|EMBL:EKC36488.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC36488.1};
RN [1] {ECO:0000313|EMBL:EKC36488.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC36488.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; JH816387; EKC36488.1; -; Genomic_DNA.
DR AlphaFoldDB; K1QS48; -.
DR HOGENOM; CLU_000335_0_0_1; -.
DR InParanoid; K1QS48; -.
DR OMA; HCKNKHT; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EKC36488.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
SQ SEQUENCE 1057 AA; 120032 MW; 061CD67FCE69CCEA CRC64;
MVQSYQTETP NCIRSVLYSD EEQCLQPDVL WRQPGTVRFT HPPSNEGDDD EDNKDCPVPA
APGADFLPAS QLDPFIDFEP SQIFRSSQNK ASKEKVLKEI PNDSFRTPSE KSNPPMVSQS
QGRQLFKPPT KANHFQAPGK GESRNIQSNS SNDNSALRSR TLSDSAAIQD FSLTQPGNNV
QIVSPSTVPA LKKKYYTPSP LVLNQGQNAG VELKSTKEIA EKYRCVFPFP YFNIVQTKVF
DEIFYKDSQI VVCAPTGAGK TVVFELAIIR LLMKTEHTSL GANFKIVYMA PIKALCSERC
SDWSEKFERF GLKCRELTGD SELDDYYQLQ QEKWDSMTRR WRDNTFIVQS ICLFLIDEVH
VLSDASRGAT MEAVISRMKT IQASMNRCPP GTSTPRLRFV AVSATIPNIQ DIAEWLGDKV
PAVNFNMDDS LRPVRLRKVV LGFPFDEQKG SDFQFDMSLS YKLARIINTY SDNKPTLVFC
STRKSTQQAA EILVKDIGST YIKTYFQRQA LQTCANSLKD NKLRDLVARG VGYHHAGLDV
HDRKAIEEIF LEGQLMVLVA TSTLAMGVNL PAHLVVLKST SYYNLGVHVE YSDTQILQMM
GRAGRPQFDT TATAVIMTKN QTKQKYESLV NGTQLIESSL HKNLIEHLNA EIVLHTINDI
SIAMEWIRYT FLYIRVMKNP KHYGKCMPLG MNREQIEKRL QELCMRNLNL LNTHGMITMD
DETIDVKSTE PGKLMARYCI AFETMRRFSK LGPTERIAEL LYEMCGCDEF SEVQLRNNEK
KTLNTFNRDK NRITVRFPVT GKIKTKQMKV NILIQVALGC LLLQDFSLQQ DSTRIFRAAQ
RMSRCLVELL WLKDEYKSLL SGVQLMKCLK ARLWEDSRYV SKQLDGIGPA LSNALVNAGI
TTFQKISDTN PRELELVSKY SEDMADIVVH LVIANPEEVG TRRTLPENHT CVLLIGDEDN
RVVYKRKIMD LGYVTTIDEM ATIQQRNGCD RNLKLVDILK KKTGGFQAFT EALLQEKYSN
EHFVNKMRDN LKLLNSKPRV VPEDSKKQTS TTNNQTI
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