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Database: UniProt
Entry: K1QSL7_CRAGI
LinkDB: K1QSL7_CRAGI
Original site: K1QSL7_CRAGI 
ID   K1QSL7_CRAGI            Unreviewed;       861 AA.
AC   K1QSL7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   07-JUN-2017, entry version 16.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CGI_10018452 {ECO:0000313|EMBL:EKC34209.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Pteriomorphia;
OC   Ostreoida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC34209.1, ECO:0000313|Proteomes:UP000005408};
RN   [1] {ECO:0000313|EMBL:EKC34209.1, ECO:0000313|Proteomes:UP000005408}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC34209.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W.H., Paps J.,
RA   Zhu Y., Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J.,
RA   Wen B., Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D.,
RA   Xu Z., Liu Y., Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B.,
RA   Cheng P., Jiang X., Li J., Fan D., Wang W., Fu W., Wang T., Wang B.,
RA   Zhang J., Peng Z., Li Y., Li N., Wang J., Chen M., He Y., Tan F.,
RA   Song X., Zheng Q., Huang R., Yang H., Du X., Chen L., Yang M.,
RA   Gaffney P.M., Wang S., Luo L., She Z., Ming Y., Huang W., Zhang S.,
RA   Huang B., Zhang Y., Qu T., Ni P., Miao G., Wang J., Wang Q.,
RA   Steinberg C.E.W., Wang H., Li N., Qian L., Zhang G., Li Y., Yang H.,
RA   Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; JH816385; EKC34209.1; -; Genomic_DNA.
DR   EnsemblMetazoa; EKC34209; EKC34209; CGI_10018452.
DR   InParanoid; K1QSL7; -.
DR   OMA; WTAYDAH; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000005408; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005408};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005408};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    403    429       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    436    453       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    529    547       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    559    586       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    623    641       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    792    817       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    121       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   861 AA;  98654 MW;  7220E730CF8482B7 CRC64;
     MGSLFRSEEM TLCQLFLQSE AAYACVSELG ELGLVQFRDL NPDVNAFQRK FVNEVRRCDE
     MERKLRFLEK EIKKDGIPML DTGDNPDAPV PREMIDLEAT FEKLENEMKE VNGNTEALKR
     NYLELTELKH ILRKTQTFFE EAEIHHVQAM HDPSLTEENF GLLGEEQSHR AGQALRLGFV
     AGVIVREKIP AFERMLWRVC RGNVFLRQAE IDTPLEDPVT GDQVNKSVFI IFFQGEQLKS
     RVKKICEGFR ATLYPCPETP AERREMAIGV MTRIEDLNTV LGQTQDHRHR VLVAAARNIK
     IWFIKVRKIK AIYYTLNMLN LDVTQKCLIA ECWCPVQDLD RIQQALRRGT ERSGSSVPSI
     LNRMKTKEVP PTYNRNNKFT QGFQNIIDAY GISTYQEVNP APWAIISFPF LFAVMFGDFG
     HGFIMFLIFD MFFGGRYIIL LMGFFSMYTG LIYNDIFSKS VKLFDSSWDP HDPQTNLRYT
     AGTLNGSVSL TLDPNVSFIK GGPYPFGLDP VWALSSNKIT ALNSFKMKLS VIFGVSQMAL
     GVVLSIVNHR FFNRKLDIYC GFIPQVIFLI SIFGYLVCEI FIKWIIFTVK DAPTAPNLLI
     GLIQMFLFQT EEKNIWYSGQ RGFQAFLVVL AGICVPWMWL IKPLYQRHQQ KHGQYKYQQV
     PTGNLLDDSE GEEVVYHSDS ERSHYDPEPE VTLGLQTVLT PQRFKHQPLS VNSGDIIGQD
     YQGEGQIDVT VEEEFDFGEA FTHQSIHTIE YCLGCVSHTA SYLRLWALSL AHAQLSEVLW
     NMVMRIALQI DGYGGAFLLA AVFSFWACAT VVVLILMEGL SAFLHTLRLH WVEFNSKFYD
     GQGYKFHPFS FDDLSEYSIE D
//
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