ID K1QXN0_CRAGI Unreviewed; 463 AA.
AC K1QXN0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Acid sphingomyelinase-like phosphodiesterase 3b {ECO:0000313|EMBL:EKC41652.1};
GN ORFNames=CGI_10022056 {ECO:0000313|EMBL:EKC41652.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC41652.1};
RN [1] {ECO:0000313|EMBL:EKC41652.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC41652.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the acid sphingomyelinase family.
CC {ECO:0000256|ARBA:ARBA00008234}.
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DR EMBL; JH818186; EKC41652.1; -; Genomic_DNA.
DR RefSeq; XP_011452681.1; XM_011454379.2.
DR AlphaFoldDB; K1QXN0; -.
DR GeneID; 105345969; -.
DR KEGG; crg:105345969; -.
DR HOGENOM; CLU_014743_0_2_1; -.
DR InParanoid; K1QXN0; -.
DR OMA; IMMAPSI; -.
DR OrthoDB; 205363at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00842; MPP_ASMase; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR045473; ASM_C.
DR InterPro; IPR041805; ASMase/PPN1_MPP.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR PANTHER; PTHR10340:SF59; METALLOPHOS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10340; SPHINGOMYELIN PHOSPHODIESTERASE; 1.
DR Pfam; PF19272; ASMase_C; 1.
DR Pfam; PF00149; Metallophos; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 30..279
FT /note="Calcineurin-like phosphoesterase"
FT /evidence="ECO:0000259|Pfam:PF00149"
FT DOMAIN 291..436
FT /note="Sphingomyelin phosphodiesterase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF19272"
SQ SEQUENCE 463 AA; 53366 MW; 2FB4EDA4DAB4FAC8 CRC64;
MERPHLLFVL LLVVSAEFQV KCVQAKEGWF LHVTDFHWDY TYGSQDWSCN DNVSNHGLYG
DYWCDSPWNL ITSAVEAMKN ATEDRDADFI LWTGDNVLHV GDDKVNIDIH DQILGNLTQL
LRTHFPTVPV YATYGNHDYY PHDQFPPHNN ELYNRTLEQW KSWINDVQQE DNFRKGGYYT
VKTTSGIRIL ALNTNLYYTS DKVTAGLIDP ADQFSWMENV LASSNASNEK VIVTGHVPPG
MAPPLGTRWM YEDFHQKLNS ILYKYSNIII GMHFGHEHND NFRVFYDEQD KPVLGLFMAP
SVTPWRFKIP SLGVTGKAHN PGFRMIRYDQ STGRHLDLIQ YFMDLPESNR MQAPVWKTGY
TATSDMSIPD ITPASMDLFV KRMADPNGAD FKKFYSWRFS SAEHPSVGVC DQSCHAIIHC
NFIHSSKKKY DQCVNLLTSN ATSIFLMWFY MFLVVVACFM NIL
//
