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Database: UniProt
Entry: K1R2B8_CRAGI
LinkDB: K1R2B8_CRAGI
Original site: K1R2B8_CRAGI 
ID   K1R2B8_CRAGI            Unreviewed;       792 AA.
AC   K1R2B8;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   13-SEP-2023, entry version 40.
DE   RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE            EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN   ORFNames=CGI_10007768 {ECO:0000313|EMBL:EKC39913.1};
OS   Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX   NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC39913.1};
RN   [1] {ECO:0000313|EMBL:EKC39913.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC39913.1};
RX   PubMed=22992520; DOI=10.1038/nature11413;
RA   Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA   Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA   Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA   Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA   Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA   Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA   Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA   Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA   Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA   Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA   Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT   "The oyster genome reveals stress adaptation and complexity of shell
RT   formation.";
RL   Nature 490:49-54(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; JH818748; EKC39913.1; -; Genomic_DNA.
DR   AlphaFoldDB; K1R2B8; -.
DR   HOGENOM; CLU_011614_4_0_1; -.
DR   InParanoid; K1R2B8; -.
DR   OMA; CRVEEMS; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR   Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR038158; H-NOX_domain_sf.
DR   InterPro; IPR011644; Heme_NO-bd.
DR   InterPro; IPR011645; HNOB_dom_associated.
DR   InterPro; IPR042463; HNOB_dom_associated_sf.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07700; HNOB; 1.
DR   Pfam; PF07701; HNOBA; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
SQ   SEQUENCE   792 AA;  89563 MW;  BA54CF2FA2EB1381 CRC64;
     MKSEDDSPKH SRDGTPTTLK CPKKMYGLLL ESVENYIKEK YGEDVWEKIR KMSHVETMAF
     STHKRYSENI IPDIARACAI VLDLPEEEIM DSFGVSFVTF VGQYGYDKIL SVLGRNMRDF
     LNGLDNLHEY LRFSYPKLRP PSFFCTNEST SGLTLHYRSK RKGFVHYVKG QIRQVGKLFY
     KVEIHIDVVS IEVHDNMTHV VFRLHFENDA YKEEMVKRQA FASNSLPLNS GVFFNLFPFH
     IVFTRSFEIK GIGSGISAVF PSAKGQKINA LFTLTRPLID FKWDKILEHT NNVFELKSYK
     SLKRPGCPFQ ELAKEVLKKE KEQEKVLNAV SPTDTISDDG LDGEDQEGGR SLDKESSDED
     DGNHIRLKGQ MMYMMEWECI IFLATPILES PDAMFKSGLY INDLSMHDSS RDLVLAGTQQ
     SAELKLALDQ EQQKSKILEE SMRKLDAEMK RTDSLLYQMI PKPVADRLRR GEPAITTCQV
     FDNVTILFSD VVGFTSICSQ ISPMEVVCML NAMYTKFDQL SERHGVYKVE TIGDAYMVVS
     GAPEITVYHA LNICNMALDM IASMVELSDP STGGHMRIRV GIHSGTTVAG VVGIKMPRYC
     LFGDTAMKIH ISETTWNHVS DHPYRVEERG SIPIKGKGNL KSYWLLGLDE NDELLPKSVG
     GTPRKESRTT PQFDGRSLYS PISFDDLPRK RSMDASLDII KQNERNNSLE VTSPNKRNGS
     LDMTSRPFRA ADNQGSCSPQ KDLQFNFRKN SGTVNGDQST TMTFVPDSKN RFSGGVEKGF
     LGEEKSSLCQ IL
//
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