ID K1R2B8_CRAGI Unreviewed; 792 AA.
AC K1R2B8;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 13-SEP-2023, entry version 40.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=CGI_10007768 {ECO:0000313|EMBL:EKC39913.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC39913.1};
RN [1] {ECO:0000313|EMBL:EKC39913.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC39913.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JH818748; EKC39913.1; -; Genomic_DNA.
DR AlphaFoldDB; K1R2B8; -.
DR HOGENOM; CLU_011614_4_0_1; -.
DR InParanoid; K1R2B8; -.
DR OMA; CRVEEMS; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF10; SOLUBLE GUANYLATE CYCLASE 88E; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134}.
SQ SEQUENCE 792 AA; 89563 MW; BA54CF2FA2EB1381 CRC64;
MKSEDDSPKH SRDGTPTTLK CPKKMYGLLL ESVENYIKEK YGEDVWEKIR KMSHVETMAF
STHKRYSENI IPDIARACAI VLDLPEEEIM DSFGVSFVTF VGQYGYDKIL SVLGRNMRDF
LNGLDNLHEY LRFSYPKLRP PSFFCTNEST SGLTLHYRSK RKGFVHYVKG QIRQVGKLFY
KVEIHIDVVS IEVHDNMTHV VFRLHFENDA YKEEMVKRQA FASNSLPLNS GVFFNLFPFH
IVFTRSFEIK GIGSGISAVF PSAKGQKINA LFTLTRPLID FKWDKILEHT NNVFELKSYK
SLKRPGCPFQ ELAKEVLKKE KEQEKVLNAV SPTDTISDDG LDGEDQEGGR SLDKESSDED
DGNHIRLKGQ MMYMMEWECI IFLATPILES PDAMFKSGLY INDLSMHDSS RDLVLAGTQQ
SAELKLALDQ EQQKSKILEE SMRKLDAEMK RTDSLLYQMI PKPVADRLRR GEPAITTCQV
FDNVTILFSD VVGFTSICSQ ISPMEVVCML NAMYTKFDQL SERHGVYKVE TIGDAYMVVS
GAPEITVYHA LNICNMALDM IASMVELSDP STGGHMRIRV GIHSGTTVAG VVGIKMPRYC
LFGDTAMKIH ISETTWNHVS DHPYRVEERG SIPIKGKGNL KSYWLLGLDE NDELLPKSVG
GTPRKESRTT PQFDGRSLYS PISFDDLPRK RSMDASLDII KQNERNNSLE VTSPNKRNGS
LDMTSRPFRA ADNQGSCSPQ KDLQFNFRKN SGTVNGDQST TMTFVPDSKN RFSGGVEKGF
LGEEKSSLCQ IL
//