ID K1R9L7_CRAGI Unreviewed; 2528 AA.
AC K1R9L7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 {ECO:0000313|EMBL:EKC37890.1};
GN ORFNames=CGI_10019507 {ECO:0000313|EMBL:EKC37890.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC37890.1};
RN [1] {ECO:0000313|EMBL:EKC37890.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC37890.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH818640; EKC37890.1; -; Genomic_DNA.
DR HOGENOM; CLU_228333_0_0_1; -.
DR InParanoid; K1R9L7; -.
DR OMA; RLCLQNK; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00033; CCP; 31.
DR CDD; cd00054; EGF_CA; 6.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 31.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR19325:SF567; LOCOMOTION-RELATED PROTEIN HIKARU GENKI; 1.
DR Pfam; PF00008; EGF; 4.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00354; Pentaxin; 1.
DR Pfam; PF00084; Sushi; 31.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00032; CCP; 31.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 31.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS51828; PTX_2; 1.
DR PROSITE; PS50923; SUSHI; 31.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DISULFID 299..308
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 337..346
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 375..384
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 413..422
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 451..460
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 489..498
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 731..758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 789..816
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 821..864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1030..1057
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1088..1115
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1146..1173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1204..1231
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1262..1289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1320..1347
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1379..1406
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1436..1463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1488..1515
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1550..1577
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1608..1635
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1666..1693
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1723..1750
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1964..1991
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2024..2051
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2082..2109
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2140..2167
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2198..2225
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2315..2342
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2373..2400
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2431..2458
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 2528 AA; 274880 MW; BA76EBA1D66426C3 CRC64;
MHLCFLHLTL VLSVRYLGQY QKKAQQLPAA NQTQEVTEQL KGMLTVVKTE GGGGTLDIKV
GGTKAKFANL TISKAGPRYK CKEGGVLVNT SCVKCPVGTF FNVVSKSCSG CPIGTYQPLE
GSVACLVCPI NTTTDHNNSK SEQECKAQCL PGTYSWDGLE RCATCQVGFY QQEYGQTTCV
KCPPGTTTKR RGSRVLEKCE EPCKPGYVSS SGLKPCFPCP KGTYQSDPGQ TVCYECPRKA
LTMFTASTDV TNCSGSKAIS DNQLQADEPE VVVYNDCFES KCQNGATCRR KLIGFTCDCP
PGYKGLYCES RLDHCEGSPC LNGGQCNNHL TNFTCTCAAG FTGSKCEINI DDCISMPCEN
NGTCQDLAND FACSCPEFFK GPTCNTTVDF CTPSPCLNNG VCQQRLGGYN CTCPTGFRGT
NCEINHDDCG SVPCQNGGTC EDGTASYRCQ CMLGFTGEQC EVDIDDCSPD PCLNASRCED
HVNGFTCHCQ KGFIGERCER ELEVEYLLDF PFAGTFNYTS TTIDKDLASA TVSFWMRTDD
VINQGTPFSY ASSPEMDNAF TLTSYDGFVV YVNNQQVSTD VDANDGGWHH IVFTWSSNRG
GWKIYKDGVT FDTGNGLAPG QVIKGGGTFV IGQEQDSDGS YNSAESFVGQ ITHLNVWDRE
LTFTEIENMK VSCKKFEGNV IAWVDIQTGL HGALRPEPSN FCEGCPVPAT PVYAQAEYSS
TDPGATVTYS CLRGFEFLVR NIRQCLVTGE WSGTDFQCLR VRCGYPERLP NGIITGRRYD
YESTIRYSCD NNYRLRGPER RYCNENGTWE GSTPTCEEIT CTLPLLSENT ISTPSKQHYK
ARDTVIFSCR EGYKLLTDHD FVFCQKDGTW DQSVPTCDPQ TCKHTPSVPN AVAQDTKAEY
SVGYTMTFTC NFGFRLSEVN PTGQINCLPN GHWESNIPVC EIVTCPNPPT VLHSDSDIGR
LTYLGRVTYN CDPGYELFGP TNVIECLEEG SWDPSPPECL PVECGDPGLI ANGHVTSLSY
TFKSVASYKC NYGYVLRGNG SRVCQSNKEW SGTAPVCSPV SCGQPETIEN GVFEENGDTY
GSIATYGCYP GYDLQGEAER TCEASAMWSG SAPGCTKKEC GSPPPVIHGH QTSSGVYFQD
TVNYTCETGF RLNGFSYLRC LANGEWGPLP PVCEAITCPT PEVIQNGNYT TTGDVFGSRV
EYFCLQGYIL TAESIRVCQP DGSWSSKVPS CAADECPIPL PVENGRFDFK DRSLGSVVLY
FCNTGYKLNG TDFRRCESTL SWSGDEPVCT PKSCVEPDDI LNGERNVSGM LYNSIVTYKC
DIGYNMTGSS QRTCLSSGSW SGTAPSCNPI VCDTPTKVIS NGRSFGNSST YQSVVTYICD
PGYNLNGASR RQCLISGQWD FEIPICEVVH CARPHLKNGI FSNFKTEYSS IVTFQCRSGY
VLFGASERTC LESGFWSGRS PVCVKVKEKP NVEYASVLSN GYNITYSCLY GYRLVGDPTL
QFQEDGQWHG NTPNCVPIEC NTTSLNIDNF MNGEIVVGNI TVGSSAVFTC NTGFTLTGPS
SRVCLSDGSW SGSNPICNIV YCSGKFQIDN GIISGPSNHF NSSLQFTCVP GYRLLGDDII
TCLENGSWSG SSPVCERISC SLPNDTIVLS ASYSTLTVGG NVHYTCPQNY RMIGDSLRTC
LTSGEWSGIE PTCRVKQCPI PIISNGRIEM TSRNIGSFIT YTCNEGYILV GSVGRFCTTA
ETWTQEDPTC EVIRCPSPPT IYGGIVLDNG RADFVYGDMV RYKCNEGFVI QEGDTEHICQ
GSGTWLGQLP VCASVACGPP PVIQNSASKL LNTTYTFNSV VEYTCNEGYR SQSSHSLTSK
CQASGSWSLV SFTCLKVQCP SFPTIANGNV LGDSITFGSN ISVLCDVGFI ITGESHITCL
SNGSWSIAQF PSCKRIACPI PDIISNGNVR YNELYVGDSV QYSCATGFEL VGNSKRICTG
SGQWSGNKPY CQRVVCSDPP IHPNAVVSIN TTEYYSSDEI TYSCLPGYTM TVQGRLLCNS
KGLWEGTAPT CTKIKCEQPS YIANGDPHFT DITFGSAVTY TCRSGYVLSG STSMTCLETG
SWSGARPTCN PVDCGPATPI EDGVIVGDVY TYGNSVTYIC DEGFELTGAS DLICRADRTW
SNPPPLCQRI NCGPPPTVSD ADILGNNFFF QGVVTYSCHS GYKMRGDATI VCGSNAKWSS
NVTRCELITC GEPPEIPNAR VSVSGQRSNS LATYMCSNGY TMVGDPIAVC TNTGVWSVSK
RFSCDPVDCG SPPSITNATV SYKSTTFSSY AVYRCQQGYS LQGNDRIQCG GSGLWDSSLP
VCVMELCPAP DLPSNVIIDS GTYRSGDSLV FRCSDGYDLL GSKTIACTAS GTWSSSVPNC
QIVHCPRETG VLNTQDFNQE FPYGETRSAS CKGGFETAGS LDVTCQSNGK WSTPTGYCRK
FFCGKPPVTD MINIIRVQGR SYSYRDQVRY QCRPGIQPIR NPPIITCLDT GQWDGQIACY
CTYFLRNT
//
