ID K1RAS3_CRAGI Unreviewed; 1490 AA.
AC K1RAS3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=RHD domain-containing protein {ECO:0000259|PROSITE:PS50254};
GN ORFNames=CGI_10028750 {ECO:0000313|EMBL:EKC31121.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC31121.1};
RN [1] {ECO:0000313|EMBL:EKC31121.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC31121.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; JH823244; EKC31121.1; -; Genomic_DNA.
DR HOGENOM; CLU_004343_1_0_1; -.
DR InParanoid; K1RAS3; -.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08310; Death_NFkB-like; 1.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF28; NUCLEAR FACTOR NF-KAPPA-B P110 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 11.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 7.
DR PROSITE; PS50088; ANK_REPEAT; 7.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 94..291
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
SQ SEQUENCE 1490 AA; 162013 MW; 6B813CEAA5C44551 CRC64;
MAAWNNSRVC RVCWGTVVEM LSITRPHFVM NTMVSTESRN NRTRTRGTGF PILPPPHACH
QHPCPTMEHD DSSDSVDISM MKNGIAPDYP PPHSDGPYID IVEQPQARGF RFRYECEGPS
HGGLQGEKSE KYRKTFPSIK IRNYNGAARI VVTLVTNEAI PKPHAHKLVG KNCNDGSCVV
ELKPNQNVIT FPNLCIQHVT RRKASEVIEY RILDSMKLDK QVKLGNLNVQ TDLSDDEKSQ
ASKQSKQLAK DMQLNVVRLC FQAYLRDDSG KIFHLLPPIL STAIYDSKAP GANALKICRM
DKYGGCCTGN EEVFLLCEKV QKDDIQVRFV EQDDDGKTIW EAFGNFGPFD VHRQYAIVFK
TPAYRNPNID RPVSVIIMLQ RKSDTETSEP KSFTYFPQSF DKDEIAKKRK KTLPSYPGSN
GFGGGGGGGE DGRPSINNFH NGGLSFGPPQ GNIPVMVNDS EQSLSNDSLH NPSPPPKISN
ATKRRINKAK RQGIKPSEVE VDGNRVQGLP TFISEPSSLQ VAGPPEIHVT SAANFQPNHN
INLQQFNHVN AQNFASHIYV PRGGGGLTTA RDAMNDSTSS SSGMDEVDAT VCDKNFRTQR
DNGSFVLRKD LMMPQDTSPD SGRETPNDIE SDGQPLVTVQ SIMEACVTET ADVTEKTAEL
KLEAICSSEE QVLAQSVDTA SIDSGESIQS AVSERCDQSV QTDKDEVVRT TERTVQALQT
YATTGDIRQL LLVQRYLTSV PDQNGDIPLH TAIINGNTEV VNNLLDVMQT MPNLWLKINA
YNNLLQTPLH LAVLTGQEEV IDRLLCAGAN TKLPDRNGNN PAHLAVLMGN TSCLARLLKY
QRPFSTPKNP FPELNMKNFD GFAPAHIAAQ KGNLQAIKLL VRCKADINMA DGKSGKTPLH
YAAEENDLSA GAFVDAICFN GNTALHIACG RQNSGMVALL MAAGANPEIE NSEALKNELS
SEDEEEEVEK VLPGHKPRHY AAGNSRILKI LNGEPYGGDS IGGMKSLTGR SDFYLEANSL
LASEDFQGPP TLRSSLSSVT CPPTISAVLS SSDDHSSSDV LSTTPLHLAV LTGQEEVIDR
LLCAGANTKL PDRNGNNPAH LAVLMGNTSC LARLLKYQRP FSTPKNPFPE LNMKNFDGFA
PAHIAAQKGN LQAIKLLVRC KADINMADGK SGKTPLHYAA EENDLSAGAF VDAICFNGNT
ALHIACGRQN SGMVALLMAA GANPEIENSE ALKNELSSED EEEEVEKVLP GHKPRHYAAG
NSRILKILNG EPYGGDSIGG MKSLTGRSDF YLEANSLLAS EDFQGPPTLR SSLSSVTCPP
TISAVLSSSD DGDIEKISYP VRVQLSKLLD PPQAGSDWVA LAERLGLRQS VEGHQGGFSP
TRLLLTFYES CGGTVSKLLE ALVAMERYDA VELINSALSI RTDDCKREAI GRDIAGGRPE
GHLQISFPGP YSAAAQVMAR GRKWSMVGCA FVKSGRDLKS SNLAFLSAGE
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