ID K1RBA4_CRAGI Unreviewed; 928 AA.
AC K1RBA4;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Vacuolar protein sorting-associated protein 11 homolog {ECO:0000256|PIRNR:PIRNR007860};
GN ORFNames=CGI_10013198 {ECO:0000313|EMBL:EKC43018.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC43018.1};
RN [1] {ECO:0000313|EMBL:EKC43018.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC43018.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004492}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004492}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004492}.
CC -!- SIMILARITY: Belongs to the VPS11 family.
CC {ECO:0000256|ARBA:ARBA00007070, ECO:0000256|PIRNR:PIRNR007860}.
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DR EMBL; JH817349; EKC43018.1; -; Genomic_DNA.
DR AlphaFoldDB; K1RBA4; -.
DR HOGENOM; CLU_001287_0_1_1; -.
DR InParanoid; K1RBA4; -.
DR OMA; ENECPAC; -.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0099023; C:vesicle tethering complex; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR PIRSF; PIRSF007860; VPS11; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR007860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
SQ SEQUENCE 928 AA; 107632 MW; 39FA9D405B7038EF CRC64;
MAFLQWRRFN FFDKEILKDT ESDQVYDKLK DVNISACVSG RGQLIVGDHE GYVYLINKQL
SLNMFKAYEI RVSHLYQLKQ HNLLVSIGED EQGINPLIKV WNLDKMEKGG PLCTRISRAI
PNNKATPVTC LVVHENLNWM AVGFENGSVM LFKGDVTRDR HNKSRIVHET SRPVTALEFR
TQGKNIFLFV VTEASVVSIN ISGKQDAKNT LEQFGGKLGG VVMSDHNQDN QLVVARPDAV
YFYQSDSRGP CLAFEGEKLR LHWFRNYLIV VGKEDKTLPR PVQLGGQTME MNIVTVYDIQ
NKFIAYSAPF PDVIDVLSEW GCVYILGGDR KIYQLQEKDT QTKLEMLFKK NNYTLAISLA
KSQQYDQEGL IDIFTQYGDH LYSKGDHDGA IDQYIKTIGK LEASYVIRKF LDAQRIHNLT
KYLQALHKQQ QATEEHTTLL LNCYTKLKDV NKLDEFIMTK DREVDFDVET AIRVCRQAGY
FEHALFLAEK HGKHEWYLRI QLEDIKQYQR ALQYISKLEF SEAEKNVKRY GKVLMAEVPQ
ETTELLKRLC TDYRPTDKPL VDQNMYDGTV GHIEKAQAEN FIHIFVNNSE RLTEFLEHMI
RVQPNSPSLL YNSLLELYLH DIVHETDSMK KTERVRKTEE LLKNPDAKYD LDQAMVLCQM
NDFKVGILYL YEKAHLYQQI LRYHMEHDDY VNVIETCKKF GQQDSNLWVQ ALSYFARKED
DCKPQLMEVL SQIDKKNLLP PLLVIQTLAH NSTATLSVVK DYIIRRLQME NDQIAEDERL
IKQYREDTDK KRAQIEELKT TAKVFQASKC NICNHPLELP SVHFLCEPHS YHQHCFESYA
ENDSECPVCA AENRKIMDII RAQEQSRDLH EQFHNQLQRS QDGFSVVADY FGRGVFNKVT
LITDSPARQT SKSPATSRSP PNPSIQYY
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