ID K1RGK2_CRAGI Unreviewed; 856 AA.
AC K1RGK2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|ARBA:ARBA00029538, ECO:0000256|PIRNR:PIRNR028921};
GN ORFNames=CGI_10028900 {ECO:0000313|EMBL:EKC42924.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC42924.1};
RN [1] {ECO:0000313|EMBL:EKC42924.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC42924.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport
CC pathways. {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Early endosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Lysosome membrane
CC {ECO:0000256|PIRNR:PIRNR028921}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR028921}. Golgi apparatus, trans-Golgi network
CC {ECO:0000256|PIRNR:PIRNR028921}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR028921}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR EMBL; JH817099; EKC42924.1; -; Genomic_DNA.
DR RefSeq; XP_011438559.1; XM_011440257.2.
DR AlphaFoldDB; K1RGK2; -.
DR HOGENOM; CLU_001285_2_2_1; -.
DR InParanoid; K1RGK2; -.
DR OMA; PQLVWQD; -.
DR OrthoDB; 8838at2759; -.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0034058; P:endosomal vesicle fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR CDD; cd16690; RING-H2_Vps41; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019453; VPS39/TGF_beta_rcpt-assoc_2.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF10367; Vps39_2; 1.
DR PIRSF; PIRSF028921; VPS41; 1.
DR SMART; SM00299; CLH; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR028921};
KW Endosome {ECO:0000256|PIRNR:PIRNR028921};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR028921}; Lysosome {ECO:0000256|PIRNR:PIRNR028921};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}; Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Transport {ECO:0000256|PIRNR:PIRNR028921};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
SQ SEQUENCE 856 AA; 98547 MW; 7D006B3EEB8846FD CRC64;
MATSTSDEPQ VDKSEDEEET SSEESEEDCE PTLKYERIGN DMKNKLLSKD CVSCLAVHSK
FLVVGTHWGM IHIFDHAGNA IRDKEIAAHT TTVNQLSIDD QGDHIASCSD DGRVMISGLY
TADNNQTVNF DRPVKAVAID PKFGKHGSGK NFVTGDDKLI LNERGGLFNR HKSTLLHQGE
GLIREIKWKG EFIAWTNDHG VKIFDMTSRS RITFISKDHS YRPDQYKCNM CWKDGHTLLL
AWADKVKVCK VKERAERDVR DLPEKYVEIT AMFTIDSFAC GISPLGESLV ILTFEKELQE
EGNRQVSKRP HLLIVEPHME YFEEISNDAL TVRGFQEYKP SDYHLETIED ENLFYIVSPK
DIIVSKERDT DDHVAWLLER EEFEEAMEVA EKNEHLLRKL TQKGVAMKYL EYLLEMGNYE
EAARQCPRIL GKNKESWEEQ TWKFQKLRQL KALAPYLPRT EPQLSPAIYE LVLNDFLNTD
CEKFLNLVKE WPSNLYNVQT IITATLDRLD RERNNTVLLR ALGELYTLER QYEKSLAIYL
KLGNTDVFQL IHKYNLFSSI SDKIVQLMEF DEDQAAKLLI ENMDKLPIEQ VAKQLENHQK
YLFTYLDRVC QKDQQLCQPY HGQLVKLYAE FAPHKLLPFL KSSIHYPLQG AMDECQVRGL
IPEQVYLLGR MGDLKKALSL ITTQLKDVDQ AIAFCKDKND EELWADLIKF SIDKPSFIKG
LLHNIGTHVD PIRLIPQIQN GMKIPGLRDS LVKILQDYNL QMSLREGCKR ILVADSFNLL
DRFVKTQKRA VSVDNGQVCP ICQERILVTD LKYASNVVLF YCKHAYHEDC LPTHAQERCS
ICSTQRRGPG SKAVVK
//
