ID K1S0H7_CRAGI Unreviewed; 1010 AA.
AC K1S0H7;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Phosphatidylinositol-glycan-specific phospholipase D {ECO:0000256|ARBA:ARBA00015988};
DE EC=3.1.4.50 {ECO:0000256|ARBA:ARBA00012284};
DE AltName: Full=Glycosyl-phosphatidylinositol-specific phospholipase D {ECO:0000256|ARBA:ARBA00029753};
GN ORFNames=CGI_10021257 {ECO:0000313|EMBL:EKC40766.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:EKC40766.1};
RN [1] {ECO:0000313|EMBL:EKC40766.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=05x7-T-G4-1.051#20 {ECO:0000313|EMBL:EKC40766.1};
RX PubMed=22992520; DOI=10.1038/nature11413;
RA Zhang G., Fang X., Guo X., Li L., Luo R., Xu F., Yang P., Zhang L.,
RA Wang X., Qi H., Xiong Z., Que H., Xie Y., Holland P.W., Paps J., Zhu Y.,
RA Wu F., Chen Y., Wang J., Peng C., Meng J., Yang L., Liu J., Wen B.,
RA Zhang N., Huang Z., Zhu Q., Feng Y., Mount A., Hedgecock D., Xu Z., Liu Y.,
RA Domazet-Loso T., Du Y., Sun X., Zhang S., Liu B., Cheng P., Jiang X.,
RA Li J., Fan D., Wang W., Fu W., Wang T., Wang B., Zhang J., Peng Z., Li Y.,
RA Li N., Wang J., Chen M., He Y., Tan F., Song X., Zheng Q., Huang R.,
RA Yang H., Du X., Chen L., Yang M., Gaffney P.M., Wang S., Luo L., She Z.,
RA Ming Y., Huang W., Zhang S., Huang B., Zhang Y., Qu T., Ni P., Miao G.,
RA Wang J., Wang Q., Steinberg C.E., Wang H., Li N., Qian L., Zhang G., Li Y.,
RA Yang H., Liu X., Wang J., Yin Y., Wang J.;
RT "The oyster genome reveals stress adaptation and complexity of shell
RT formation.";
RL Nature 490:49-54(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an alpha-D-GlcN-(1->6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-
CC myo-inositol + H2O = 6-(alpha-D-glucosaminyl)-1D-myo-inositol + a
CC 1,2-diacyl-sn-glycero-3-phosphate + H(+); Xref=Rhea:RHEA:10832,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57997,
CC ChEBI:CHEBI:58608, ChEBI:CHEBI:58700; EC=3.1.4.50;
CC Evidence={ECO:0000256|ARBA:ARBA00034002};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the GPLD1 family.
CC {ECO:0000256|ARBA:ARBA00008652}.
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DR EMBL; JH818314; EKC40766.1; -; Genomic_DNA.
DR AlphaFoldDB; K1S0H7; -.
DR HOGENOM; CLU_011756_0_0_1; -.
DR InParanoid; K1S0H7; -.
DR OMA; KWWKKEH; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004621; F:glycosylphosphatidylinositol phospholipase D activity; IEA:UniProtKB-EC.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 3.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR001028; Gprt_PLipase_D.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR029002; PLPC/GPLD1.
DR PANTHER; PTHR23221; GLYCOSYLPHOSPHATIDYLINOSITOL PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR23221:SF7; PHOSPHATIDYLINOSITOL-GLYCAN-SPECIFIC PHOSPHOLIPASE D; 1.
DR Pfam; PF01839; FG-GAP; 4.
DR Pfam; PF00882; Zn_dep_PLPC; 1.
DR PRINTS; PR00718; PHPHLIPASED.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
DR PROSITE; PS51470; FG_GAP; 4.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 9..174
FT /note="Phospholipase C/D"
FT /evidence="ECO:0000259|Pfam:PF00882"
SQ SEQUENCE 1010 AA; 112630 MW; 52D9AB0E53BAF24D CRC64;
MPAYVCRMIA ERAKDSFQEN SHYRKLMDIH EDAFNGGAPY PDAFYDDICF KGIYHDVSED
THWGEFLNVS INYINKLPKP WDMATEKLFV FVMALMSHQV ADITWHSLYL EQGFLPTMGY
MNFHGSYSNA HPVGDFGNHQ FLYLPVDDLY NIYKEFYGKT RIDKDTIELC SGLLLLSEIA
EILLGSEPFL VIANDSNFLI DNEMEYFQGG LTDMASLTTR KWNDAITMIE QGVQACHVPH
STVFINCTKG LDRSPDNLAP VKKSRYQRPR LYDLTMDDLR ITPSLRGVKI QMADKLKDRV
LDRKRKDYNF FQRKSFEFAE SGNKRQPNFT IDYSSSRNYS QLGWSLVAKD LDGDGNEDLV
VGSPGYSTSN EPQRGRVYIL YSGDSGLPVG ASPFVDIDNM TLGYNKILEG NPGEYSRFGY
ALAAIDINLD GNMDIAVSAS SLSYRGLLDY NGVVYVYFGS GVKRSWNSKP DLVITCQMQF
CNLGSSMTSL DINNDGKDDL VIGSPFASVK NLTQNGMVTA LLSSNSLVSG MVIPVEKLTQ
TWILFGNQSY SWFGHRLNAK KKQLLVSQPY YRLCKSCGSY LATDIQSVGK LNIYSFGKSF
NTKPSLSING RNRFDQAGYS SDIGDPFGNG SSILAVGIPG MDVIGRVDSS SEKFTQGGGV
VLMTTELKEV AQFTGDRMFS RFGSVVKFSD VNGDGIDDLL ISAPIRNDNP TILINSRING
KVYVFYGGSQ FPLNNATVSP VCGSISPCSE ILANLTLGYG LDWKTDFGKP MTILKCKQQV
QIVVSAPGNG DNFKSRTMKQ SGNLHSVDMD GVSVDLYILH TVWTAACAVA IRWARAMNIY
QHCIITVLFL AVVGDIGSVL NTLWSSGFEL ASSSSGFLLP VAESAQSGVL NKIQQNKGKK
NNTILKHKLQ GKNGTNRIRW GKKNKGDKKH WTVDDKKKVF KPKWWKKEHK WWKKEHVKGH
GKAGAHGNWR FGQKGGNGRW GGGSRNRTNS TSSRGRGWRQ GWSKHWKLDG
//
