ID K1U0K2_9ZZZZ Unreviewed; 259 AA.
AC K1U0K2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Type III pantothenate kinase {ECO:0000256|ARBA:ARBA00040883};
DE EC=2.7.1.33 {ECO:0000256|ARBA:ARBA00012102};
GN ORFNames=LEA_03085 {ECO:0000313|EMBL:EKC78822.1};
OS human gut metagenome.
OC unclassified sequences; metagenomes; organismal metagenomes.
OX NCBI_TaxID=408170 {ECO:0000313|EMBL:EKC78822.1};
RN [1] {ECO:0000313|EMBL:EKC78822.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22891823; DOI=10.1111/j.1462-2920.2012.02845.x;
RA Ferrer M., Ruiz A., Lanza F., Haange S.B., Oberbach A., Till H.,
RA Bargiela R., Campoy C., Segura M.T., Richter M., von Bergen M., Seifert J.,
RA Suarez A.;
RT "Microbiota from the distal guts of lean and obese adolescents exhibit
RT partial functional redundancy besides clear differences in community
RT structure.";
RL Environ. Microbiol. 15:211-226(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP +
CC H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC EC=2.7.1.33; Evidence={ECO:0000256|ARBA:ARBA00001206};
CC -!- COFACTOR:
CC Name=K(+); Xref=ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00001958};
CC -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC pantothenate: step 1/5. {ECO:0000256|ARBA:ARBA00005225}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the type III pantothenate kinase family.
CC {ECO:0000256|ARBA:ARBA00038036}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKC78822.1}.
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DR EMBL; AJWY01002060; EKC78822.1; -; Genomic_DNA.
DR AlphaFoldDB; K1U0K2; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004594; F:pantothenate kinase activity; IEA:InterPro.
DR GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 2.
DR HAMAP; MF_01274; Pantothen_kinase_3; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR004619; Type_III_PanK.
DR NCBIfam; TIGR00671; baf; 1.
DR PANTHER; PTHR34265; TYPE III PANTOTHENATE KINASE; 1.
DR PANTHER; PTHR34265:SF1; TYPE III PANTOTHENATE KINASE; 1.
DR Pfam; PF03309; Pan_kinase; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coenzyme A biosynthesis {ECO:0000256|ARBA:ARBA00022993};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKC78822.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 259 AA; 27457 MW; 3AED67882E35220B CRC64;
MLLALNIGNT NVTFGGYDSA GQRVFASRFY SDSALSSDEL VYKLVNMLAL YHIQPRDVDA
AILASVVPVL TSRMREALEK MTNAPLMEVG PGLKSGVRIR MDNPAQLGGE LLCAAVGALQ
THKPPLLVMN MDTAATLVAV DAEGSIVGGV ILPSPALSLS ALVRNTAQLP QIDMELPAKR
FLGTNTTDCL HSGIVNGSAL MLDGLFARCR ATLHAPDAPV IATGTLPASI RDACATPIEY
NGTLILDGLY SIWKRNVKK
//
