ID K1WHI0_MARBU Unreviewed; 743 AA.
AC K1WHI0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Hexokinase {ECO:0000313|EMBL:EKD12291.1};
GN ORFNames=MBM_09612 {ECO:0000313|EMBL:EKD12291.1};
OS Marssonina brunnea f. sp. multigermtubi (strain MB_m1) (Marssonina leaf
OS spot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Drepanopezizaceae; Drepanopeziza.
OX NCBI_TaxID=1072389 {ECO:0000313|EMBL:EKD12291.1, ECO:0000313|Proteomes:UP000006753};
RN [1] {ECO:0000313|EMBL:EKD12291.1, ECO:0000313|Proteomes:UP000006753}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB_m1 {ECO:0000313|EMBL:EKD12291.1,
RC ECO:0000313|Proteomes:UP000006753};
RX PubMed=22876864; DOI=10.1186/1471-2164-13-382;
RA Zhu S., Cao Y.-Z., Jiang C., Tan B.-Y., Wang Z., Feng S., Zhang L.,
RA Su X.-H., Brejova B., Vinar T., Xu M., Wang M.-X., Zhang S.-G.,
RA Huang M.-R., Wu R., Zhou Y.;
RT "Sequencing the genome of Marssonina brunnea reveals fungus-poplar co-
RT evolution.";
RL BMC Genomics 13:382-382(2012).
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225}.
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DR EMBL; JH921460; EKD12291.1; -; Genomic_DNA.
DR RefSeq; XP_007297501.1; XM_007297439.1.
DR AlphaFoldDB; K1WHI0; -.
DR STRING; 1072389.K1WHI0; -.
DR GeneID; 18765547; -.
DR KEGG; mbe:MBM_09612; -.
DR eggNOG; KOG1369; Eukaryota.
DR HOGENOM; CLU_014393_5_0_1; -.
DR InParanoid; K1WHI0; -.
DR OMA; HYESHIR; -.
DR OrthoDB; 5481886at2759; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000006753; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.40.367.20; -; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR019807; Hexokinase_BS.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443:SF30; GLUCOKINASE-1-RELATED; 1.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00378; HEXOKINASE_1; 1.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKD12291.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000006753};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 123..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..397
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 407..709
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 743 AA; 80658 MW; 0DFD8A03E506B805 CRC64;
MSPRTSPRTR RLGKQRTRCP HRTQAEAELG RRHPVQIQTQ DAGSRSWEQP GASFADLSNQ
AHARSWLCYG AHLGTRYQYN AILCQLHRQP LTAIVPLPSP DKPKTFREPA RSYRVSTLSR
NPFSLVQLAS FALLALVLIA QFYFADNPPN YLRVNPFSST SESLPAQVGS GTCENPTPFG
PVPSQSSPIS KPHTMALQAA TQKVVKEFTL LDEDLQKIEG LEKNDTTMAQ IPTYVTAGLY
MAVDLGGTNF RVCSIQLNGD TTFNLIQSKV AVPQELMRAK TAKELFAFLA KQIELFLKTH
HQDQFSAHIR RRATISTPEG FRDEHVFRLG FTFSFPVHQV GINRGRLMRW TKGFDIPDAI
GQDVCILLQR EIDALKLPVK VAALVNDTVG TLMARGYTSP GKTGSLLGAI FGTGTNGAYV
EKLAAITKPL EGEFDKRTGE MVVNTEWGSF DNGLKTLPST PADIQLDAES INPGMQMFEK
RISGMFLGEL LRLTLVSMIK DPAVPLFSDD NSSQNDYRST ASVEANAPLH IKNAVDSSIL
SFSEADHSDG LRAVRQAIYM NLGVSAASVE DAQAVKEISH AIGLRAARLA AAAIGAIVIH
TGRLNTGPPT KPVPTAASII SDVKNLKLAD AASATASKLA DTAGLTVNED EIVDIGVDGS
LVEFYPGFMD SMREALRSMP EIGAAGERKI RIGIAHDGSG VGAALIALVA AKMESKQDYM
GELRNQLDGL VEQEEAIDDE DSA
//
