ID K1XA40_9BACT Unreviewed; 334 AA.
AC K1XA40;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 22-FEB-2023, entry version 33.
DE SubName: Full=Tartronate semialdehyde reductase {ECO:0000313|EMBL:EKD21932.1};
DE EC=1.1.1.60 {ECO:0000313|EMBL:EKD21932.1};
DE Flags: Fragment;
GN Name=garR {ECO:0000313|EMBL:EKD21932.1};
GN ORFNames=ACD_87C00257G0001 {ECO:0000313|EMBL:EKD21932.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD21932.1};
RN [1] {ECO:0000313|EMBL:EKD21932.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD21932.1}.
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DR EMBL; AMFJ01037311; EKD21932.1; -; Genomic_DNA.
DR AlphaFoldDB; K1XA40; -.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000313|EMBL:EKD21932.1}.
FT DOMAIN 30..188
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 191..311
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 197
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKD21932.1"
SQ SEQUENCE 334 AA; 35035 MW; B04D55095213EC51 CRC64;
NPAYKAGLTG CAPGHAGMIP AGGAQMQKCV GIVGIGFMGQ AFTANLLRAG FSLRGFDKDS
GRMKEFQDQG GIAASSAAEA ARGARWVLTS LPNSAVVREA VFGPGGIAEG AERGLLITDA
TTSRPEDSAS LATELEDRGI RFLDAAVSGT SAMAWKKDLI VVAGGKPEDF EACRPLFDGF
AKAAYHMGPV GSGALAKLII NLVLDCNRLG LAEGLVLGLK AGLNMDSLLV ALKEGAAGSK
TMDQKGAKMI YADYTPESHL TTALKDVRLM LEQGQRFGVP MLLTSIFAQI AQIGVESGYA
KYDSSSIMEV LRQMAGLPTV KTDKEERQPF TQPE
//
