ID K1ZT90_9BACT Unreviewed; 560 AA.
AC K1ZT90;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Sodium/hydrogen exchanger {ECO:0000313|EMBL:EKD52882.1};
GN ORFNames=ACD_61C00209G0008 {ECO:0000313|EMBL:EKD52882.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD52882.1};
RN [1] {ECO:0000313|EMBL:EKD52882.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD52882.1}.
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DR EMBL; AMFJ01025701; EKD52882.1; -; Genomic_DNA.
DR AlphaFoldDB; K1ZT90; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF6; CONSERVED INTEGRAL MEMBRANE TRANSPORT PROTEIN-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 403..525
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 560 AA; 61192 MW; 893B358746143D96 CRC64;
MDVFLVNLMI VFSVAVFFGI IFRYIGLPSV VGQVLAGFVI GLSGLLGSQS IESMRLLGSL
GVTLLLFLVG LEMNLREIKN TGKTVIKIFL IQTVLLGLLF FIFSGLLLKL NIVSSILLAI
ALTFSSTIVV VKTLSEKRDL GSFSGKLSLG ILLLQDLVAI FVLALIPGFS HGFDLSALGA
LSIKILVLFL TINIFGHFLI SQIEKYLIKT TEDLVLISLV WFSLAVYFSV NVLGLTPEIG
GILAGISLST TWGHFQIVSK VKTLRDIFLT VFFVLLGLEI GTGSVNWLLV FELVFLALVI
KFVVAELSCY WSGLSGKVAF SLSVNMTQFS EFSLIVLSFG LVSGFWDNEL VTAVTMAGLI
SMVVSTIFIL RSSQLYKFLS EHSPKIFKFD GLHKGSLVSM RGHVVLLGGD RTGRSILSSM
KKIGEKVLVV DFNPDIVNHL HSRGEEAIFA DASDPDIADI ANMTDAKMII STIKDVDDSL
SLLLLLKQKG IAVPTIVDAE TAAQAAMLYE AGASYVIFPH FVSGLHLGLV MKKFEKDADA
LKKYRQRQNE TLKEIYEGEF
//
