ID K2AK85_9BACT Unreviewed; 444 AA.
AC K2AK85;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Mur ligase central domain-containing protein {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=ACD_52C00312G0001 {ECO:0000313|EMBL:EKD62077.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD62077.1};
RN [1] {ECO:0000313|EMBL:EKD62077.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD62077.1}.
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DR EMBL; AMFJ01022754; EKD62077.1; -; Genomic_DNA.
DR AlphaFoldDB; K2AK85; -.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR Gene3D; 3.90.190.20; Mur ligase, C-terminal domain; 1.
DR Gene3D; 3.40.1190.10; Mur-like, catalytic domain; 1.
DR InterPro; IPR036565; Mur-like_cat_sf.
DR InterPro; IPR004101; Mur_ligase_C.
DR InterPro; IPR036615; Mur_ligase_C_dom_sf.
DR InterPro; IPR013221; Mur_ligase_cen.
DR PANTHER; PTHR43024; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR PANTHER; PTHR43024:SF1; UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE; 1.
DR Pfam; PF02875; Mur_ligase_C; 1.
DR Pfam; PF08245; Mur_ligase_M; 1.
DR SUPFAM; SSF53623; MurD-like peptide ligases, catalytic domain; 1.
DR SUPFAM; SSF53244; MurD-like peptide ligases, peptide-binding domain; 1.
PE 4: Predicted;
FT DOMAIN 153..255
FT /note="Mur ligase central"
FT /evidence="ECO:0000259|Pfam:PF08245"
FT DOMAIN 282..359
FT /note="Mur ligase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02875"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKD62077.1"
SQ SEQUENCE 444 AA; 49526 MW; D38F9E2E773D8173 CRC64;
CLRLAARIQL FKIRPQIVGL TGSVGKTSLR NAITAVLSGT YRVKYSKKAN SETGIPLDLL
DLHPRDYSLG DWVRLGLSVP IQLLVNWKKY DVYVVELGID DPFPPKNMEY LLRFIKPDIG
VFLNVAPVHT EQFSKLLPSD VVVSPKQKTR LILQAIALEK GKIITRLPAD KIAVVNRDDV
LVWKQAQKTK ARVVTFGKQD QSKVIIKSVT HQFAAKNRLR PQDVQTHLEF RYQGHTYGLS
LPLLVPDYYA STLAAALTVG LQMGITMEKI LMALGERFVL PPGRMSLFAG THQSLIIDSS
YNASKQSTLG TLELLSKIPQ KPKVVVLGDM RELGAVAGSE HGIVAKKILA VADQVILIGP
LTRKYVLSVV SPKLPTRWFA NSWEAAAWLK KKLKAGSVVL VKGSQNMIFT EVVVEQLLAY
SQDKNSLCRR GRYWNEQRQK SRLA
//
