ID K2AM45_9BACT Unreviewed; 251 AA.
AC K2AM45;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE Flags: Fragment;
GN ORFNames=ACD_57C00243G0003 {ECO:0000313|EMBL:EKD57533.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD57533.1};
RN [1] {ECO:0000313|EMBL:EKD57533.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD57533.1}.
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DR EMBL; AMFJ01024685; EKD57533.1; -; Genomic_DNA.
DR AlphaFoldDB; K2AM45; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0009378; F:four-way junction helicase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00016; DNA_HJ_migration_RuvB; 1.
DR InterPro; IPR041445; AAA_lid_4.
DR InterPro; IPR004605; DNA_helicase_Holl-junc_RuvB.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008824; RuvB-like_N.
DR InterPro; IPR008823; RuvB_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00635; ruvB; 1.
DR PANTHER; PTHR42848; -; 1.
DR PANTHER; PTHR42848:SF1; HOLLIDAY JUNCTION ATP-DEPENDENT DNA HELICASE RUVB; 1.
DR Pfam; PF17864; AAA_lid_4; 1.
DR Pfam; PF05491; RuvB_C; 1.
DR Pfam; PF05496; RuvB_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 2..100
FT /note="RuvB-like P-loop"
FT /evidence="ECO:0000259|Pfam:PF05496"
FT DOMAIN 103..176
FT /note="RuvB AAA lid"
FT /evidence="ECO:0000259|Pfam:PF17864"
FT DOMAIN 178..248
FT /note="RuvB C-terminal winged helix"
FT /evidence="ECO:0000259|Pfam:PF05491"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKD57533.1"
SQ SEQUENCE 251 AA; 27861 MW; 9328A65ED4685524 CRC64;
GIKITSGPAL TRAGDLASIL TGLEQNDILF IDEIHRLSKV VEEALYPAME DRAIDIILGK
GPGAKSLRLD LLPFTLVGAT TQAGKISAPL RDRFGIVHRL NFYEPEELSE IILKAAQKME
LNLDKESAIE IAKRSRGTAR IALKLLRRVR DFTYVEHKSE LNSENTKKSL EFYMVDDEGL
DDTDRRLLLA IINQHGGGPV GLETLAALIS ESVETISDLY EPYLLQSGFL SKTSKGRVAT
DKSYTHLKIK R
//
