ID   K2B4M7_9BACT            Unreviewed;       417 AA.
AC   K2B4M7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Adenylate/guanylate cyclase with Chase sensor {ECO:0000313|EMBL:EKD68621.1};
GN   ORFNames=ACD_47C00516G0003 {ECO:0000313|EMBL:EKD68621.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD68621.1};
RN   [1] {ECO:0000313|EMBL:EKD68621.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23019650; DOI=10.1126/science.1224041;
RA   Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA   VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA   Long P.E., Banfield J.F.;
RT   "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT   bacterial phyla.";
RL   Science 337:1661-1665(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKD68621.1}.
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DR   EMBL; AMFJ01020668; EKD68621.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2B4M7; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        120..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        146..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        174..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          235..368
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   417 AA;  46628 MW;  E32A294A635EDF79 CRC64;
     MKNDRFAVNF NMYSREGGVT TVEQRGVDLK LAGGSDFYIN YGISSNYIKP VSFYKIVTGE
     YDPRWFEGKI VLVGATVRSL HDDFPTPLML RDRATTPGVF IHAYAQATFL ENAFIRETGG
     WLNFIITLAV CLVLAFIIFE RTPLTAFIIS LALAAAHLVF TTGAFYARVN MHSVTPQIAF
     FLTYVLMSSY KYLKEEREKQ MIKGIFKQYV TPEVVDELLR DPEKLTLGGE KKSVTILFAD
     IRNFTRLSEQ IAPETVVELL NSYFDAMLEI VYKHGGILDK YLGDGMMVIF GAPVADENST
     INALRCALEM QKASIEFSRS RRAANLATID GIGIGLNTGE VVVGNIGSQK HKEYTIIGDN
     VNLTARIVSI ALVNQVLISE NTYRLLSSKA EVKKQETVKL KGKSNPVNIY EIIKLNE
//