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Database: UniProt
Entry: K2BZ18_9BACT
LinkDB: K2BZ18_9BACT
Original site: K2BZ18_9BACT 
ID   K2BZ18_9BACT            Unreviewed;       123 AA.
AC   K2BZ18;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   22-FEB-2023, entry version 21.
DE   SubName: Full=Bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/5,10-methylene-tetrahydrofolate cyclohydrolase {ECO:0000313|EMBL:EKD78786.1};
GN   Name=folD {ECO:0000313|EMBL:EKD78786.1};
GN   ORFNames=ACD_41C00265G0001 {ECO:0000313|EMBL:EKD78786.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD78786.1};
RN   [1] {ECO:0000313|EMBL:EKD78786.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23019650; DOI=10.1126/science.1224041;
RA   Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA   VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA   Long P.E., Banfield J.F.;
RT   "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT   bacterial phyla.";
RL   Science 337:1661-1665(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKD78786.1}.
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DR   EMBL; AMFJ01017147; EKD78786.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2BZ18; -.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099:SF5; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000313|EMBL:EKD78786.1}.
FT   DOMAIN          2..118
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   123 AA;  12805 MW;  E75D0879B2E046B3 CRC64;
     MLIGAGSLVG RPLANMLFHE QATVSVLNRS TKNMAHYTKT ADVIITGVGK PNVLTGAMIK
     PGAVVIDAGV SFVGKHMYGD IDFASVSKKV KLVTPTPGGV GPLTVAKLIE NTVKCAQKLS
     KES
//
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