ID K2CEF2_9BACT Unreviewed; 479 AA.
AC K2CEF2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Aldehyde dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF00171};
GN ORFNames=ACD_41C00091G0008 {ECO:0000313|EMBL:EKD79373.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD79373.1};
RN [1] {ECO:0000313|EMBL:EKD79373.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD79373.1}.
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DR EMBL; AMFJ01016973; EKD79373.1; -; Genomic_DNA.
DR AlphaFoldDB; K2CEF2; -.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR PANTHER; PTHR11699:SF211; ALDEHYDE DEHYDROGENASE FAMILY 16 MEMBER A1; 1.
DR PANTHER; PTHR11699; ALDEHYDE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345}.
FT DOMAIN 20..470
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 251
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 479 AA; 51281 MW; 03B04E6DA19456D2 CRC64;
MAYPKTVSHW INNQAVMGAS GATFDKVNPA TGAVFANVAR GNAADVDAAI QAAQRAYPLW
SQTNIVERAE KLRAVAQLIQ QRISEIAEIV HLETGKAVAD AEGEAKAAME MGFFVAGEGR
RFYGKTTTSA MPNRTAMTVR QPLGVCGLII AANTPLPNVA WKAFPALLCG NTVVLKPSED
IPYTAIWFAE LIKEVGVPAG VFNVVQGFGT EVGAPLVADT RVPLISFTGS VTVGKQINKV
AGERLAKVCL ELGGKNPFVV CDDADLETAA DFAVQSAFSN AGQRCAAGSR IIVFASVYDQ
FKKFFVERAQ QFEAGPVINE RQLNNMSTAV DQAVQAGATV LLGGQRLVDT AHAKGFYYAP
TILENVKSTD AISCEEVFGP ITILYKVKDF QEALDLANDT EFALTAAIHT SSIHRIQEFQ
DKCVAGVISV NGPSHGSEPH LPFGGEKNSG TGWREAGTEA LDVYSDWKTI YIKHLPDHV
//
