ID K2DPE6_9BACT Unreviewed; 761 AA.
AC K2DPE6;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 13-SEP-2023, entry version 40.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
DE Flags: Fragment;
GN ORFNames=ACD_17C00507G0001 {ECO:0000313|EMBL:EKE07821.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKE07821.1};
RN [1] {ECO:0000313|EMBL:EKE07821.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE07821.1}.
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DR EMBL; AMFJ01006658; EKE07821.1; -; Genomic_DNA.
DR AlphaFoldDB; K2DPE6; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}.
FT DOMAIN 597..613
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKE07821.1"
SQ SEQUENCE 761 AA; 86319 MW; A6271ABC5FB14481 CRC64;
PFHTAESYID KLLLNGFKIA IAEQIEDPKE TKGIVKRALV RVLTPATIIN SQLINDKKNN
FFVSIVLEES HFGLAILDIT TAEFRVMEID KMQHVMDELC RLKPKELLIS KDFEFLKELS
HYFPFVATLR SPLSLQMAQE VLNGHFDAND KEKKAGTIAA GSLLFYLQEE LLLNLEHLQK
VDTESEAEWM ALDRSTMKNL EIQESLIQLL DETSTPMGGR LLCHFVQYPL LSPEKIFERQ
EQIACFIRQQ DLAKTLMKLL SQIKDIERLI MKIAGKYAGP RDLYALGRSL TQIPEVKKLL
PQERLGHFDD LSKRILSAMN DSPPLKAHEG EVFRDGYHQE LDSLRKLAKD SMSWMAQYQL
HLREETGIKT LKVGYTRAFG YYIEVPRAQS GRIPDTFHRR QTLVNAERFL TQELKDFEHR
VLTAEERSKA IELELFEHLR KEIAKESGPI HQAAKTIAKI DVMLALTTIA VRNQWTRPIV
DHSDTLEIIG GRHPVIESHV GRASFIANDT HLSPKQQLLL ITGPNMAGKS TYIRQVALIA
ILAQMGSYVP ATSTRMGIID KIFSRIGASD DIARGQSTFM VEMSETANIL NNATSRSLVL
LDEIGRGTST YDGISIAWAV AEYLLTTHRK QAKTLFATHY WELTRLKNHF PNAANVQTAV
KEIDSGIVFL RKIIPGGTDK SYGIHVAKLA GLPNQAIQRA EEMLKELERG FVHSVDKEEQ
MSFLLSAAKE HPVLNRLKKI DLLHLTPIQA QHLLCELKNM I
//
