ID K2DUS1_9BACT Unreviewed; 404 AA.
AC K2DUS1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Integrase {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACD_23C00882G0002 {ECO:0000313|EMBL:EKD97523.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKD97523.1};
RN [1] {ECO:0000313|EMBL:EKD97523.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- SIMILARITY: Belongs to the 'phage' integrase family.
CC {ECO:0000256|ARBA:ARBA00008857}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKD97523.1}.
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DR EMBL; AMFJ01009420; EKD97523.1; -; Genomic_DNA.
DR AlphaFoldDB; K2DUS1; -.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0075713; P:establishment of integrated proviral latency; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0044826; P:viral genome integration into host DNA; IEA:UniProtKB-KW.
DR CDD; cd00801; INT_P4_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 3.30.160.390; Integrase, DNA-binding domain; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR038488; Integrase_DNA-bd_sf.
DR InterPro; IPR025166; Integrase_DNA_bind_dom.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR PANTHER; PTHR30629; PROPHAGE INTEGRASE; 1.
DR PANTHER; PTHR30629:SF2; PROPHAGE INTEGRASE INTS-RELATED; 1.
DR Pfam; PF13356; Arm-DNA-bind_3; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01248};
KW Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 98..179
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 204..381
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
SQ SEQUENCE 404 AA; 44706 MW; EEF2CBB730AEAA5E CRC64;
MSLTDTAIKK AKPGDKPVKL SDGKGLYLLV NPVGSKLWRW KYRFLGKEKV MSLGAYPDVS
LAQARDGMGA ARKLLASGTD PMAQRASEKI TKQASAENSF QSVALLWWDH WHGAKSARHA
DDVMRRLKAD VFPAIGARPV SEIQAHELVA MVQTIAKRGA LDIAKRALQT SGQVLRYAVA
HGLAHRNPAS DIKPSDVLAS RKAGNYARIS AKELPELLRH IDGYAGAAVT RLAMKLMALT
FVRTSELIGA RWAEFDLEAR RWDIPASRMK MKTPHIVPLS TQAVNVLQTL QLVSGRSTLL
FPGERDHEKS MSNNTILGAL DRMGYKGRMT GHGFRGVAST LLHEMGFDHA HIELQLAHQE
RNEVSAAYNH ATYLQQRSKM MQHWANYLDS CTTGRVLVFQ RAAA
//
