ID K2FMH3_9BACT Unreviewed; 820 AA.
AC K2FMH3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ACD_6C00695G0004 {ECO:0000313|EMBL:EKE22882.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKE22882.1};
RN [1] {ECO:0000313|EMBL:EKE22882.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE22882.1}.
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DR EMBL; AMFJ01002062; EKE22882.1; -; Genomic_DNA.
DR AlphaFoldDB; K2FMH3; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR CDD; cd07731; ComA-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR035681; ComA-like_MBL.
DR InterPro; IPR004477; ComEC_N.
DR InterPro; IPR004797; Competence_ComEC/Rec2.
DR InterPro; IPR025405; DUF4131.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR NCBIfam; TIGR00360; ComEC_N-term; 1.
DR NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR Pfam; PF03772; Competence; 1.
DR Pfam; PF13567; DUF4131; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 451..472
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..193
FT /note="DUF4131"
FT /evidence="ECO:0000259|Pfam:PF13567"
FT DOMAIN 248..529
FT /note="ComEC/Rec2-related protein"
FT /evidence="ECO:0000259|Pfam:PF03772"
FT DOMAIN 561..637
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 820 AA; 93522 MW; E4AEAA3277D8E2D3 CRC64;
MLQWLCIGWI LGLACMGKSF LSVQLSGTVV LIVALLWYMG CHKLKFISNT PLRSLLITGS
GLLLGLFLGH AYANLQLAER LSKREHEVFE KEIVVYIKEL NKLGDQNIQQ ALHVLNPDGT
TVKWMGFLPI SDPATSRLVN DETKQQTLEL GHYYLLQGQI RPNHSYAAPG AFDAEKWALQ
QNVMAGFRIK HIRELQLQQL YALGHAQHLR QQKNLNQRFL LWVEQQRLAL REFVARQPVQ
QKGLLLALLS GDESLLDQST EQKFQRFGMS HLLAISGPHV LIFAFIVCGT LQYLISRYAP
QIYLKWPRQY FLSLPFLLCV LLYCAFVGFE IPALRTLLIC VIVTFTLLLR QSVQPLKLLI
LSAALLLLFD PFSILSAAFW LSYGACFVLL RIYQTIQQQP HQKIQTALQR LYFAMKVLVE
SQWKIFLALL PLMMLFFKQV AWITPLSNLV AIPWIGLLIV PVDILAALLF FISEPLSSLL
FQLNDIFIHI LLAFLNLLDR LFAPQLIPVA MNVWMIALCI LGLLIVFLPR GLVPKSWTAL
ACLPLCIPQL NQHAFQLSVL DVGQGQAIFI REGQKSMMID MGGYYNEEKF SIGRQVIMPF
LSVQGVGEMD QLILTHLDQD HSGAYHSIKD QLNIRQVSSN QMPETATSSS FQFCYEGQQW
QWSEEINFKI LAPRQQQLNT PNFNKNDRSC VIYLQVKNAG PYQKFLLMGD AGWETEYQLL
QNYPELKVDV LVLGHHGSQH SSAYQFLQVL KPKLAIASAG KFNRYGHPSQ LTQQRLKALN
IPLLTTAEQG SVHFQQQGSK LVLSAERHEW QWLYRQPLSD
//
