ID K2FRM9_9BACT Unreviewed; 225 AA.
AC K2FRM9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=ACD_6C00135G0006 {ECO:0000313|EMBL:EKE24387.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:EKE24387.1};
RN [1] {ECO:0000313|EMBL:EKE24387.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23019650; DOI=10.1126/science.1224041;
RA Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA Long P.E., Banfield J.F.;
RT "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT bacterial phyla.";
RL Science 337:1661-1665(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE24387.1}.
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DR EMBL; AMFJ01001502; EKE24387.1; -; Genomic_DNA.
DR AlphaFoldDB; K2FRM9; -.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 25..221
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
FT REGION 43..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 225 AA; 23866 MW; BE5654E483665A60 CRC64;
MKILIVLTSH DQLGNTGKKT GFWLEELAAP YYTFIDSGAE VTLASPQGGQ PPLDPKSNLA
DAQTETTHRF EADPTAMQAL TQTHKLSEIS VADYDAVFYP GGHGPLWDLA EDPISISLIE
QAIQSGKPVA AVCHAPGVLR HVKASNGAPL VSGKLVTGFT NTEEAAVGLT EIVPFLVEDM
LKENGGHYSK VDDWQVHVQV DGLLVTGQNP ASSAATASAL LQLLK
//
