ID   K2FTA3_9BACT            Unreviewed;       593 AA.
AC   K2FTA3;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Peptidoglycan glycosyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=ACD_7C00379G0005 {ECO:0000313|EMBL:EKE21029.1};
OS   uncultured bacterium.
OC   Bacteria; environmental samples.
OX   NCBI_TaxID=77133 {ECO:0000313|EMBL:EKE21029.1};
RN   [1] {ECO:0000313|EMBL:EKE21029.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23019650; DOI=10.1126/science.1224041;
RA   Wrighton K.C., Thomas B.C., Sharon I., Miller C.S., Castelle C.J.,
RA   VerBerkmoes N.C., Wilkins M.J., Hettich R.L., Lipton M.S., Williams K.H.,
RA   Long P.E., Banfield J.F.;
RT   "Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated
RT   bacterial phyla.";
RL   Science 337:1661-1665(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKE21029.1}.
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DR   EMBL; AMFJ01002618; EKE21029.1; -; Genomic_DNA.
DR   AlphaFoldDB; K2FTA3; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.30.450.330; -; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF1; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE FTSI; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          66..217
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          260..569
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   593 AA;  65765 MW;  E417D79CD39139B6 CRC64;
     MQKTILSIGK NRSDKLVSSQ RIYFLAVAVF FMGVIIIARL YILQIRDHAR FRTMADDQHG
     AFSELSAKRG EIYLKNRDEK YPLAVNKEYM MVFLEPKMVA EKDRVVSELS YILGMERIEI
     EKKLSNPEDM FEIVKKKISQ EEADKITELK LKGVKLLGEN YRYYPGKELA SQIVGFVGSN
     GEQEIGRYGL ESFWEEELQG KNGSIFQERD SAGRWISITD RKKVPAQDGA DLVLTIDQAV
     QYEIEKILKL TMEKYKADGG SILVQEPSTG KLLAMASYPN FNPNEFGKVE NMSVFTNPAI
     TNAYESGSVF KTVTLASGID AGVISPNTTY VDNGVISEAG YNIKNSDGKS NGTQTMTQVL
     EKSLNTGVIF TEKLMGNKKF AEYVRNFGFG EKTGITLPNE AAGDVRNLNN LKSDIQFFTA
     SFGQGITTTP LQILNAYSVI ANGGNLMRPQ VVEKKIYSDG REESVEPKII RRVIKEETAK
     QMKEMLESVV VNGHGKRAAV SGYRVGGKTG TAQVAKQGGG GYEESITIGS FTGIAPLDNP
     RFAVIVKIDN PKDVQWAESS AAPTCGEVLK FLLNYYNVEP TEPIIKETQV SKP
//