ID   K2H048_ENTNP            Unreviewed;       590 AA.
AC   K2H048;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=ENU1_122340 {ECO:0000313|EMBL:EKE39592.1};
OS   Entamoeba nuttalli (strain P19) (Amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=1076696 {ECO:0000313|EMBL:EKE39592.1, ECO:0000313|Proteomes:UP000006769};
RN   [1] {ECO:0000313|EMBL:EKE39592.1, ECO:0000313|Proteomes:UP000006769}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P19 {ECO:0000313|EMBL:EKE39592.1,
RC   ECO:0000313|Proteomes:UP000006769};
RA   Hannick L., Karamycheva S., Lorenzi H., Caler E.;
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; JH927471; EKE39592.1; -; Genomic_DNA.
DR   RefSeq; XP_008858069.1; XM_008859847.1.
DR   AlphaFoldDB; K2H048; -.
DR   EnsemblProtists; EKE39592; EKE39592; ENU1_122340.
DR   GeneID; 20074245; -.
DR   VEuPathDB; AmoebaDB:ENU1_122340; -.
DR   OMA; CENSPQL; -.
DR   OrthoDB; 26518at2759; -.
DR   Proteomes; UP000006769; Unassembled WGS sequence.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR14336:SF8; DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE; 1.
DR   PANTHER; PTHR14336; TANDEM PH DOMAIN CONTAINING PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          15..114
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          451..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        451..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   590 AA;  65273 MW;  45E12094AC55B80A CRC64;
     MSERKITVSV ASLQPAQFTG WGTKQGGSWK SWKRRFFVLK DRKLWYFESE NSTTAKGWID
     LPPGTDVKDE SERPKKLAFS INSRGVKGIR TFHLTVDTEN DFVAFLNGLN KVLGNVKQKT
     KIDNSIIDET SKIKFTKSFT EGTGIENITK LKNRIKWLNS GQVASLLECA LTALPEDTKS
     IDFCAVVSSD CNSIDFRFAG EQVPMLQTVV DTFWAVGTPP SEIERLNNIG IKVDPRNLGL
     WLNISERGGM DGGWFMLTEH SPNVIKLVSD GGKINDKIMM LLGVNGINKI DMIGRDLGVT
     PPRQTEYRFK ISGHERANIV KDFFEKSKIK GYNLLIQKIV NDAPSREVLF SVKTTNFDLV
     KLTIIIEFPT SEIVQDAVEL VKGFNVEKHN DLIVMFGNPI ALEISCLQQG FGYEVFDEGL
     GVALVYNLQD ENITTVPFKK SLVTTSSRHC NKQQSSCENS PQLSSSVTQE QTNDNNLPQE
     DHETISQDVS SHTTTYGQQE TTQTIPAVPP LSPRRKKQVV GLTQGSGSAP PPVPPLSPRR
     QAEQKLGLSS RPTGAAPSLP GRPLGAPPRK PAAKPKHKQQ INPAQSSPVI
//