ID K2H0R5_ENTNP Unreviewed; 635 AA.
AC K2H0R5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Protein kinase domain containing protein {ECO:0000313|EMBL:EKE39847.1};
GN ORFNames=ENU1_112900 {ECO:0000313|EMBL:EKE39847.1};
OS Entamoeba nuttalli (strain P19) (Amoeba).
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=1076696 {ECO:0000313|EMBL:EKE39847.1};
RN [1] {ECO:0000313|EMBL:EKE39847.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P19 {ECO:0000313|EMBL:EKE39847.1};
RA Hannick L., Karamycheva S., Lorenzi H., Caler E.;
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JH927224; EKE39847.1; -; Genomic_DNA.
DR RefSeq; XP_008857821.1; XM_008859599.1.
DR AlphaFoldDB; K2H0R5; -.
DR EnsemblProtists; EKE39847; EKE39847; ENU1_112900.
DR GeneID; 20073997; -.
DR VEuPathDB; AmoebaDB:ENU1_112900; -.
DR OMA; WEIVTRE; -.
DR OrthoDB; 333539at2759; -.
DR Proteomes; UP000006769; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004709; F:MAP kinase kinase kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR017421; MAP3K7-like.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR46716; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7; 1.
DR PANTHER; PTHR46716:SF1; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EKE39847.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 338..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 350..631
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 635 AA; 72885 MW; ADA25F94EBF8CB3F CRC64;
MIWCAMGRFI IFSNSTVFVS NNNLKCHECP NYSLNQINAI EYRPTTCNNE TNTINMKLLE
TRPSGVTMAI YSIDLQLSYS LDSYGLPSYI EVIVGENEPE RYELEDEVVN DECSDCVKNK
EITYSPPYGQ IGTEIQFRGL GNIICISKIE VIQFFTIEAL NIIDYYPVLG PIEGGTYITF
IGSNFNSKEE YYCLINGIKI ESEKINEQQR SCITPKNKNQ SQIKIQLFSE NFPLTALTNV
TFDYYDVLFE SARIYKDNEG SNQQIEVCGK GIIKSNNIEC LISSQGINET RVGGIYLNEE
CVLCFYNTEG ITTPIEIIIL LNGQNKSNSV ILRINQKITY GIIILIVLTI LIIILITIGM
FIVIYRIYNK RKKDNIKGWI NINELYLNNK ISIKTKSVIW MVSWKGVKFV LKDQMIDNSN
EFEQIKENIK TIKEIRHPCI IQYFGYSIEY PHLYLLMEFM PKHSLFNVLH SNLKIIPIAT
KFRIINEISK GLAYLHDLNP PIIHGNLNSN NVLVEQNYSI KLSDICLGFN LSLNDSIPWK
APEVLTGNKP TTKSDIYSFG IILWEIITNQ IPFDDIDLKD DLILNIVLGQ RPPLINSIPF
PCKELLLSCW KINTERLISI DEIVMKVESW KNTQF
//
