ID K2KQ61_HELPX Unreviewed; 314 AA.
AC K2KQ61;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein {ECO:0000313|EMBL:EKE84609.1};
GN ORFNames=OUG_1102 {ECO:0000313|EMBL:EKE84609.1};
OS Helicobacter pylori R32b.
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=1145112 {ECO:0000313|EMBL:EKE84609.1, ECO:0000313|Proteomes:UP000006767};
RN [1] {ECO:0000313|EMBL:EKE84609.1, ECO:0000313|Proteomes:UP000006767}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=R32b {ECO:0000313|EMBL:EKE84609.1,
RC ECO:0000313|Proteomes:UP000006767};
RX PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT "Genome sequences of 65 Helicobacter pylori strains isolated from
RT asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT disease, or gastritis.";
RL Pathog. Dis. 68:39-43(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKE84609.1}.
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DR EMBL; AMOS01000003; EKE84609.1; -; Genomic_DNA.
DR RefSeq; WP_000589025.1; NZ_AMOS01000003.1.
DR AlphaFoldDB; K2KQ61; -.
DR PATRIC; fig|1145112.3.peg.1086; -.
DR Proteomes; UP000006767; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd03376; TPP_PFOR_porB_like; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR42897; PYRUVATE SYNTHASE SUBUNIT PORB; 1.
DR PANTHER; PTHR42897:SF2; PYRUVATE SYNTHASE SUBUNIT PORB; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 51..218
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
FT REGION 147..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 314 AA; 34998 MW; 37E9941F7A4974A7 CRC64;
MIKEVKTLKG FSQSAEKFQG SHLLCPGCGH GIIVREVLNA VDGPIVLGNS TGCLEVCSAV
YPHTSWDVPW IHIGFENGST AISGVEAMYK ALTNKGRYQG QKPKFVAFGG DGASYDIGLQ
FISGCMERGH DMTYICLDNE NYANTGGQRS GSTPLGASTS TTPAGSVSFG KKEKKKDIVN
IMASHGVPYV AQLSPNKWKD MNKKIKTALD TEGPCFINAL SPCTTEWKFE SNKTIELADM
AVDSLMFPLF EIFNGRELKI TYRPRNIIPV RDYLGAQKRF RHLFKKENEH IIEELQKDVN
ERWEYLQRRE EAKV
//
