ID   K2KV67_HELPX            Unreviewed;      1312 AA.
AC   K2KV67;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Vacuolating cytotoxin autotransporter {ECO:0000256|ARBA:ARBA00017817};
GN   Name=vacA {ECO:0000313|EMBL:EKE90257.1};
GN   ORFNames=OUM_1042 {ECO:0000313|EMBL:EKE90257.1};
OS   Helicobacter pylori R038b.
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1145115 {ECO:0000313|EMBL:EKE90257.1, ECO:0000313|Proteomes:UP000006766};
RN   [1] {ECO:0000313|EMBL:EKE90257.1, ECO:0000313|Proteomes:UP000006766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=R038b {ECO:0000313|EMBL:EKE90257.1,
RC   ECO:0000313|Proteomes:UP000006766};
RX   PubMed=23661595; DOI=10.1111/2049-632X.12045;
RA   Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
RA   Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
RA   Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
RT   "Genome sequences of 65 Helicobacter pylori strains isolated from
RT   asymptomatic individuals and patients with gastric cancer, peptic ulcer
RT   disease, or gastritis.";
RL   Pathog. Dis. 68:39-43(2013).
CC   -!- FUNCTION: Induces vacuolation of eukaryotic cells. Causes ulceration
CC       and gastric lesions. {ECO:0000256|ARBA:ARBA00002940}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKE90257.1}.
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DR   EMBL; AMOV01000005; EKE90257.1; -; Genomic_DNA.
DR   RefSeq; WP_000405485.1; NZ_AMOV01000005.1.
DR   PATRIC; fig|1145115.3.peg.1018; -.
DR   Proteomes; UP000006766; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0019867; C:outer membrane; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.130; Autotransporter beta-domain; 1.
DR   InterPro; IPR005546; Autotransporte_beta.
DR   InterPro; IPR036709; Autotransporte_beta_dom_sf.
DR   InterPro; IPR006315; OM_autotransptr_brl_dom.
DR   InterPro; IPR003842; Vacuolating_cytotoxin.
DR   NCBIfam; TIGR01414; autotrans_barl; 1.
DR   Pfam; PF02691; VacA; 1.
DR   PRINTS; PR01656; VACCYTOTOXIN.
DR   SMART; SM00869; Autotransporter; 1.
DR   SUPFAM; SSF103515; Autotransporter; 1.
DR   PROSITE; PS51208; AUTOTRANSPORTER; 1.
PE   4: Predicted;
KW   Toxin {ECO:0000256|ARBA:ARBA00022656};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   DOMAIN          1039..1312
FT                   /note="Autotransporter"
FT                   /evidence="ECO:0000259|PROSITE:PS51208"
FT   REGION          339..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1312 AA;  142122 MW;  595F821B3402EBE3 CRC64;
     MEIQQTHRKI NRPIISLALV GVLIGTELGA NTPNDPIHSE SRAFFTTVII PAIVGGIATG
     AAVGTVSGLL SWGLKQAEEA NKTPDKPDKV WRIQAGRGFD NFPHKQYDLY KSLLSSKIDG
     GWDWGNAARH YWVKDGQWNK LEVDMQNAVG TYNLSGLINF TGGDLDVNMQ KATLRLGQFN
     GNSFTSFKDG ANRTTRVDFN AKNILIDNFV EINNRVGSGA GRKASSTVLT LKSSEKITSR
     ENAEISLYDG ATLNLVSSSN QSVDLYGKVW MGRLQYVGAY LAPSYSTINT SKVEGEMNFR
     HLAVGDQNAA QAGIIANKKT NIGVLDLWQS AGLSIITPPE GGYESKTKDT PSQNNPKNDT
     QKTEIQPTQV IDGPFAGGKD TVVNIFHLNT KADGTLRAGG FKASLSTNAA HLHIGEGGVN
     LSNQASGRTL LVENLTGNIT VEGTLRVNNQ VGGAAVAGSS ANFEFKAGAD TNNATATFNN
     DIHLGKAVNL RVDAHTAYFN GNVYLGKSTN LRVNGHSAHF KNIDATKSDN GLNTSSLDFS
     GVTDKVNINK LTTSATNVNV KNFDIKELVV TTRVQSFGQY TIFGDNIGDK SRIGVVSLQT
     GYSPAYSGGV TFKGGKKLVI DEIYHAPWNY FDARNVTDVE INKRILFGAP GNIAGKTGLM
     FNNLTLNSNA SMDYGKDLDL TIQGHFTNNQ GTMNLFVQDG RVATLNAGHQ ASMIFNNLVD
     SATGFYKPLI KINNAQNLTK NKEHVLVKAR NIDYNLVGVQ GASYDNISAS NTNLQEQFKE
     RLALYNNNNR MDICVVRKYN LNDIKACGMA IGNQSMVNNP ENYKYLEGKA WKNTGVSKTA
     NNTTIAVNLG NNSTPTSSES NTTNLPTNTT NNARFASYAL VKNAPFAHSA TPNLVAINQH
     DFGTIESVFE LADRSKDIDT LYTHSGAQGR DLLQTLLIDS HDAGYARTMI DATSTNEITK
     QLNAATTTLN NIASLEHKTS GLQTLSLSNA MILNSRLVNL SRRHTNNIDS FAKRLQALKD
     QRFASLESAA EVLYQFAPKY EKPTNVWANA IGGTSLNNGS NASLYGTSAG VDAYLNGEVE
     AIVGGFGSYG YSSFSNRANS LNSGANNTNF GVYSRLFANQ HEFDFEAQGA LGSDQSSLNF
     KSALLQDLNQ SYHYLAYSAA TRASYGYDFA FFRNALVLKP SVGVSYNHLG STNFKSNSNQ
     KVALSNGSSS QHLFNASANV EARYYYGDTS YFYMNAGVLQ EFAHVGSNNA ASLNTFKVNA
     TRNPLNTHAR VMMGGELQLA KEVFLNLGVV YLHNLISNAS HFASNLGMRY SF
//