ID K2KWR3_9PROT Unreviewed; 907 AA.
AC K2KWR3;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=TH2_02045 {ECO:0000313|EMBL:EKF10109.1};
OS Thalassospira profundimaris WP0211.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Thalassospiraceae; Thalassospira.
OX NCBI_TaxID=1177928 {ECO:0000313|EMBL:EKF10109.1, ECO:0000313|Proteomes:UP000007365};
RN [1] {ECO:0000313|EMBL:EKF10109.1, ECO:0000313|Proteomes:UP000007365}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WP0211 {ECO:0000313|EMBL:EKF10109.1,
RC ECO:0000313|Proteomes:UP000007365};
RX PubMed=23209215; DOI=10.1128/JB.01903-12;
RA Lai Q., Shao Z.;
RT "Genome Sequence of Thalassospira profundimaris Type Strain WP0211.";
RL J. Bacteriol. 194:6956-6956(2012).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF10109.1}.
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DR EMBL; AMRN01000001; EKF10109.1; -; Genomic_DNA.
DR AlphaFoldDB; K2KWR3; -.
DR PATRIC; fig|1177928.3.peg.426; -.
DR eggNOG; COG0249; Bacteria.
DR Proteomes; UP000007365; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 726..742
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 652..659
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 907 AA; 98691 MW; BCA6D4E81CD3F18F CRC64;
MNQIADKSDT TPTAPSFSRD GATPMMMQFL EIKEQYQDCL LFYRMGDFYE LFFDDAVKAA
EALDIALTKR GKHQGNEIPM AGVPVHSHET YLQRLIRKGF RVAVCEQMED PAEAKKRGAK
SVVKRGVVRL ITPGTLTEDS LLDARRHNYL AAVSEVRGKI GLAWLDMSTG DFFVQPCEMA
GLGAALARLD PGEILFSEKM LNRSEVFDIY AEYKNIITPQ PTARFDAENA QLRLKKLYEV
EALDAFGGFE IAELSAAGAL IDYVELTQKG QMPRLAPPTR VAEGAAMEID AATRRSLELI
QTQSGERKGS LLSVIDRTRT GAGARLLAAR LSAPLTNADE VNKRLDLVEY FHDRDGLRSD
LRAALGECPD IERALSRLSV GRGGPRDLAA MRDGLSCAFA IGNLLNKPDG GNDGLTAQPE
ALSDHLTMMG HHGDLIDLLR RAIAESLPLL ARDGGFIAGG YHPPLDELRM LSSESKKLIA
NLQARYTEQT GISNLKVKHN NVLGYFIEVS AKTADKMMEM DEFIHRQTMA NAVRFTTVEL
SELESKVSKA GDQALALELE LFDELVSAVL AKADDIAKCA SALAGLDVSA ALAELARDQG
CIRPNIDNSL AFDITAGRHP VVEAALRENG DAPFVANDCR LEDEQSLWLI TGPNMAGKST
FLRQNALIAV LAQIGAFVPA AKAHIGVIDR LFSRVGAADD LARGRSTFMV EMVETASILN
QATDRSLVIL DEIGRGTATF DGLSIAWAVV ENLHEINQCR GLFATHYHEL TALAAKLKHL
SCHTMLIKEW QGEVVFLHEV GAGSADRSYG IHVAQLAGLP KPVIKRAEQV LKTLEKGEQG
GAVSKLADDL PLFAVAIEQA AKEERTSAPA LSDAQKALLD AVADLDPDNM TPREALDALY
RLQSLKG
//
