ID K2MK48_TRYCR Unreviewed; 1178 AA.
AC K2MK48;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Cullin family profile domain-containing protein {ECO:0000259|PROSITE:PS50069};
GN ORFNames=MOQ_010249 {ECO:0000313|EMBL:EKF26074.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF26074.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF26074.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF26074.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- SIMILARITY: Belongs to the cullin family.
CC {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC ECO:0000256|RuleBase:RU003829}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF26074.1}.
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DR EMBL; AHKC01022391; EKF26074.1; -; Genomic_DNA.
DR AlphaFoldDB; K2MK48; -.
DR EnsemblProtists; EKF26074; EKF26074; MOQ_010249.
DR OrthoDB; 155391at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 1.20.1310.10; Cullin Repeats; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11932; CULLIN; 1.
DR Pfam; PF00888; Cullin; 2.
DR Pfam; PF10557; Cullin_Nedd8; 1.
DR SMART; SM00182; CULLIN; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF74788; Cullin repeat-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50069; CULLIN_2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 740..987
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT REGION 247..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 336..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1007..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1033
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 131058 MW; 91BF638B859003ED CRC64;
MQDCPSVDDL WPGVESYLVH AAHTIRTGSA EMMDRLRDVR HRMNWYAVIY SVCSGHPQKA
SEVYHRLSLF LLNDLEVNVL RPFLHKAAHC ELPPSSSLCL QFVQQYKLFM AFRRVVLSCF
SYLDQYFTAK FRLDPVTALC VKLFYVVVYE PMREALIAEV LELADEARTA YLSDKTVPSA
CNDVQQTLLS IVEILSIVKA FSAPYGANTQ GTMAHEKKDV SNSCNYKRGV GEGRKMLAAI
AAKVVRMQSP STAPNRDAPR TLDESPRSPL NKSHNSDHSQ VEPQTGGEGY SISSSPLAKD
WDAMAYRSLD SIRMLRERLE KRSFGDLMAV HLLRSSSRNK SSHHQHNNGA GTGITSGGCE
GSAKSSVDSA GVTIVDVTQP LHFLIFSDFG LRYVEAAEMY YRKRRDMQFS SPEGWLNYIP
WVQGCLAIER SLLRDVNAPL LLSALRERIH HVLLVEVHRS IILAKEVGFR AQLDAWDRNT
EQGAGDVLRD ASSSSSSLPP MGAAMSGTCG DVDAAPSPAA CFSAHSTNPW EQLSREELGD
RIKEFVATFV STQDEACWTL LASEFASKVV VDTAALFFTY MSQLDALAPQ QLQQGEEKRP
GTQQSASSLP VQPRKTVIPM RRRRPQGGDG FSSDMDFLTQ QDLAMVLIKG LVDTSTHYNK
LICEKFNEHP PMQMAMGDAM REILNPERWG QLVVGGSMHG GMAAVNRGEL PSVLLNHDAA
KKTVAVLNKL ATMRGSKEIA VPQFLAMYCD QLCRREMDDG VTDPTDHIVY LITLVDDKDV
FLEHYKLLLA RRLLFLPSAQ RNMDREHVMM HKMHHALGRT LTYGLEAMLR DHEVTASMNE
EFSRSDVALA LPTKLRVQVL TSVHWPTYRV VPLTPCDSLA HVLKAFTDYY IGVHPSRMLH
WIHSLGTATL HAVFPKGDKE VIANNLQAHI LILISNAYNM DRGGAASSGT NDTHTTVAIR
RSLSGREIAT AMGMEFCDIY IYLVPLVKHK LYNLLVRVDP SAVAGTGQIT QSSSSLSPSN
APTTTTTTTA AAAASVDDDD DAAPSVTAPG QLLPEDHFTL NVEYTHKLRK FRLPVARPSR
GDGVKGSVVS SMHVDKTKAA LSEEIETSRR IQMDAAIVRI MKSRRSLRYY ELLDLTIQQL
SKQFVPRPRS VKMQVEDLVC RGFLRRSETD TSVFEYLA
//
