ID K2MTB1_TRYCR Unreviewed; 629 AA.
AC K2MTB1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=p450 reductase, putative {ECO:0000313|EMBL:EKF38488.1};
GN ORFNames=MOQ_001304 {ECO:0000313|EMBL:EKF38488.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF38488.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF38488.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF38488.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF38488.1}.
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DR EMBL; AHKC01005596; EKF38488.1; -; Genomic_DNA.
DR AlphaFoldDB; K2MTB1; -.
DR EnsemblProtists; EKF38488; EKF38488; MOQ_001304.
DR OrthoDB; 276396at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.360; -; 1.
DR Gene3D; 3.40.50.80; Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR003097; CysJ-like_FAD-binding.
DR InterPro; IPR017927; FAD-bd_FR_type.
DR InterPro; IPR001094; Flavdoxin-like.
DR InterPro; IPR008254; Flavodoxin/NO_synth.
DR InterPro; IPR001709; Flavoprot_Pyr_Nucl_cyt_Rdtase.
DR InterPro; IPR029039; Flavoprotein-like_sf.
DR InterPro; IPR039261; FNR_nucleotide-bd.
DR InterPro; IPR023173; NADPH_Cyt_P450_Rdtase_alpha.
DR InterPro; IPR001433; OxRdtase_FAD/NAD-bd.
DR InterPro; IPR017938; Riboflavin_synthase-like_b-brl.
DR PANTHER; PTHR19384; NITRIC OXIDE SYNTHASE-RELATED; 1.
DR PANTHER; PTHR19384:SF129; P450 REDUCTASE, PUTATIVE-RELATED; 1.
DR Pfam; PF00667; FAD_binding_1; 1.
DR Pfam; PF00258; Flavodoxin_1; 1.
DR Pfam; PF00175; NAD_binding_1; 1.
DR PRINTS; PR00369; FLAVODOXIN.
DR PRINTS; PR00371; FPNCR.
DR SUPFAM; SSF52343; Ferredoxin reductase-like, C-terminal NADP-linked domain; 1.
DR SUPFAM; SSF52218; Flavoproteins; 1.
DR SUPFAM; SSF63380; Riboflavin synthase domain-like; 1.
DR PROSITE; PS51384; FAD_FR; 1.
DR PROSITE; PS50902; FLAVODOXIN_LIKE; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 50..193
FT /note="Flavodoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS50902"
FT DOMAIN 243..470
FT /note="FAD-binding FR-type"
FT /evidence="ECO:0000259|PROSITE:PS51384"
SQ SEQUENCE 629 AA; 71318 MW; BE54BD7B032F2DFF CRC64;
MFFYLIGTIV IAAVFAWFTG ILGLNPRSHA KTPVKSAMTE TKVSSRRKEV CVLFGSQTGT
AEMFAKTLVR EGTRLGVPIR ICDAENYEGH DLEYEHLVII ICSTYGEGEP TDSMKALHDW
LMDDSRTPDE ELRNVKYAVF GLGDRQYRYF CEEGIVVDRR MAELGAQRIY GLGCGNAGQN
IEEDFDEWHR DLWPAVSRVL GIELRQDVED PMEPACRMKM WDPSEEAPLP FPKLASVLEP
TQRLPAWVPL TANTELLRNT TERSTRFIEL GIEDTIISYQ SGDHLGILPH NTDAMVNAYL
QILGVSEEEA MQVFSLQEKK TGKNVFAARV TVRTALKWYI DLAGPPRKST LRAFAHYAKD
PAEKEALLKL LRVEPESAKE YAKLSAKLRT VHGFLRKYHT ISLPLGFFLE MMPRIAPRYF
SISSDLLSHP RTVSITVAIV EGGLCTGMLR EMQIGEKIPV FVRKSKFHLP LRAKERPIVM
IGPGTGVAPL IGFLHRRNAW KKKGNVLGKA ILFFGCRRKE EDHIYSDFMT ECLENGTLST
LDVCYSREQA TKVYVQHRVL ARADEVWDIL REGGNIYLCG DAKYMAKDVE RTLVEILREK
ALMSEEDAQA YLAKLNDSER YLKDVWSAS
//
