ID K2MU52_TRYCR Unreviewed; 335 AA.
AC K2MU52;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 08-NOV-2023, entry version 26.
DE SubName: Full=Calpain-like cysteine peptidase {ECO:0000313|EMBL:EKF29234.1};
DE Flags: Fragment;
GN ORFNames=MOQ_000000 {ECO:0000313|EMBL:EKF29234.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF29234.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF29234.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF29234.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00239}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF29234.1}.
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DR EMBL; AHKC01013742; EKF29234.1; -; Genomic_DNA.
DR AlphaFoldDB; K2MU52; -.
DR EnsemblProtists; EKF29234; EKF29234; MOQ_000000.
DR OrthoDB; 5477637at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF420; CALPAIN CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 31..304
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 65
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT ACT_SITE 248
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EKF29234.1"
FT NON_TER 335
FT /evidence="ECO:0000313|EMBL:EKF29234.1"
SQ SEQUENCE 335 AA; 38310 MW; 58000898670D0F6A CRC64;
MAVAVSAEAP ESDKVFHDTV FMEKNEHISN QWVRIAELHP DGIHQPLLPA EFSREQFGQG
NHYECFMLTA LSTLVRFPSV IQNCFVSKHV RRDGRYTFQF FRGREWVKVE IDDQIPLEED
GELYIRSPTG HWWPLLLEKA YAKFYTGYEN LEGCTLQETY HDLTGNPVLN IPIDAKLAKA
AGADVTEGHY WLDLAQKIQS GQFVASVLTK DMETESMGIQ REQQYGVLEI FSMTGTSSVN
DIVIHLHNPF EDEEFIYTGP LNSKDSQWTP KLRAKYSVDD ERSIFLPLST FLKIINSMQL
CYVSTIDGDA TYFDDEWKGE TAGGNPTCVT WRKNP
//