ID K2MVN9_TRYCR Unreviewed; 1843 AA.
AC K2MVN9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=ATP-binding cassette transporter ABCA1, putative {ECO:0000313|EMBL:EKF39313.1};
GN ORFNames=MOQ_000464 {ECO:0000313|EMBL:EKF39313.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF39313.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF39313.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF39313.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF39313.1}.
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DR EMBL; AHKC01001388; EKF39313.1; -; Genomic_DNA.
DR EnsemblProtists; EKF39313; EKF39313; MOQ_000464.
DR OrthoDB; 6951at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF266; TRANSPORTER, PUTATIVE-RELATED; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:EKF39313.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 203..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..522
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..567
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 608..626
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1113..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1272..1295
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1315..1342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1354..1378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1384..1409
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1459..1480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 754..987
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1531..1761
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1843 AA; 208636 MW; 651A908E958F9323 CRC64;
MSCRKKNRIL ELKYEDSALL YIYLFFSLSV CSRRKDGEGR SEGTSKGENI VGSDLFLFYF
ICIIFSLKRS GRVWGVLCRR DCVRRCGDCL CVSCMDNADN FGSFHASEDS WMDPGGFEMD
LGYQDDAPQG NFFDQPPLPE EWRSFPQYDY PFEFQQQPAE FMQEEETGSS SQFRAYEVPE
LSFLDQFLAV VERVFRQCLR TKLGILLEVG IPIVFFCITV FVWSLWGTEQ FTETNFVNYS
HMQSFIDANF YMIHMCSRTP GGVHGLPSCN PRVPVDCKGD ESTLPVKGLC VYASVGVSLL
LHAFVNSFNG RIAELPTLDT LVVFQWLARK SLKMGSSPFG IYPKTRFSAI TSSGMLYFVG
DPTFLKGLTA ELEETSKFFN YVNGGIYNTM KEAENQFEKN PFNWGIVHVR RADRDTLDAI
IYLNSTAVPD FDEIVSDAYP GGFQFDRAEM YVLSGYLTLQ KIISEYYINQ LSPTLRLNTT
AYIASQAFVE YRQATLLMYA RDILPLIFVL AFLYSVSTRT KAIVLEKEMR IREAMLIMGM
KDFVIYAAWL VRSVSIDFFV CIIISTLLKC TYMTQSDPFI IFCVFFLFTL TTIPLSGLLS
AFFSKARLAS VLSPIIYFIL TLPNMATSET NSTLTLIFAL FSPSAFVTIL KHILADEFAR
GFSAKKLADS LYEPKTVVVL CLMLADFFIY FILMLYLDAV IPKDWGTTKH PFFFIIDPIR
WCFSKKDLYE GGGPDGRAPD GVFEHYGEEE GIVVRICGLR KVYRRGGRRF IAVKNLYWSL
REGEISVLLG RNGAGKSTTL NMMTGMVRPD GGDCYVYGLS VRHQLSRVRR EIGFCPQHNI
LWPELTCREH LEFFAKIKGL KGAELEKAVQ RMLQETNMLE KIDFPATRLS GGQKRKLSLG
LAFVGQSRLV FLDEPTAGMD VGARHRIWEF LRRMSSFHTI LLTTHYMDEA DLLGHRIGIM
KNGSLQCSGS SLFLKSRLGL GYNLTIAMTP DGDFDSIHQI VEESIPNVLF LGFSGFHLSY
CLPMSEASNF SDLLYSIESQ ANYGVCGYSI SAATLEDVFL RVSQNSDEIR MHDEDYSFLW
NCVLTRSPAL RQFGVLMKKR LQNAFRDRRM QCFQLVCPFF CVLLAMLLGL ISFKKNQELN
LSFGLYNEKV LLDTAQCEDF WGEKPLLSNV VINETHFGNA VELGSYTSDT WFTHEMPRYA
SISCIDRDLY WKMGKKNPII MLHNTSAIHQ TGVTMAAFYQ LLYKNITSGR GNISWSIGAF
RRGVDSFNSV EVILMGTILM IPFTFFPSNP VAWIVKEREC GALQLQKIAG LRFMIYWLSN
FLFDMAAYLV SVIFVIIIFA VFRRDEYVGP DTVGALSTLF FVYGLTSTIA GYLVSFFFSE
HSTAQIVVMA AGFVLGFLLL MVVFIFSLLD KTKDLSDHLR WAFRILPTYS IGECMINLSN
FKQMKMRGLV NSAFDGNVTG YPIVFLAAEF PVFLLLLLFI EHPKRRRCWN RHFNSVQGIT
NQEIPDQDTD VEEERNAVYA AKQMGVMDTL VTVCGLHKKY PNGKVAVRNL TFGVRPGEIF
GFLGTNGAGK TTTIAMLCQW LLPTSGSAAI CGHDILEESS EALKCIGYCP QFDACLAFLT
VEEQLQLYAG VRGIVRWQCD NVVSGLLQLC ELVEYRDTLA HELSGGNRRK LSVAIALVGG
PRVLFLDEPS AGMDPIARRG LWNTIEAVSD NCSVVLTTHH LEEVEVLAHR VAIMVDGTLR
CIGDQTHLKN KFGSGYEMSI RIENVELYES IVNFVSEMFP NATLNEFKGQ RFVYTLPRDA
SISDTFRILR DNKELLGITD YSVSQTSMEQ VFLRVIGEIE PDL
//
