ID K2N3B0_TRYCR Unreviewed; 1071 AA.
AC K2N3B0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Glycosyl hydrolase-like protein, putative {ECO:0000313|EMBL:EKF29081.1};
GN ORFNames=MOQ_007152 {ECO:0000313|EMBL:EKF29081.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF29081.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF29081.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF29081.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF29081.1}.
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DR EMBL; AHKC01014139; EKF29081.1; -; Genomic_DNA.
DR AlphaFoldDB; K2N3B0; -.
DR EnsemblProtists; EKF29081; EKF29081; MOQ_007152.
DR OrthoDB; 118800at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd14752; GH31_N; 1.
DR Gene3D; 2.60.40.4040; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR InterPro; IPR048395; Glyco_hydro_31_C.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF170; GLYCOSYL HYDROLASE-LIKE PROTEIN; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF21365; Glyco_hydro_31_3rd; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:EKF29081.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..751
FT /note="Glycoside hydrolase family 31 TIM barrel"
FT /evidence="ECO:0000259|Pfam:PF01055"
FT DOMAIN 759..860
FT /note="Glycosyl hydrolase family 31 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21365"
SQ SEQUENCE 1071 AA; 120595 MW; 47823B39832AA9AD CRC64;
MRRHGAIFRR GARRRFRWTL RVFIFASFLL TLIILLNGSF FTWPHYFYYF TGKGAAKVGS
SSSSSSPPPA AAAVLRVDGR GGQRVWRPTH VAPHVPSNIP TADDNAPQEG LLWPRQRHDV
DVLYSTQTCK LMADGPNGAH EGDVLMRVRF YRPNCRKGVH GGEEGKMRKR PCDDSAHPII
GLMPHQSAAS FFPEEVLMDE VNLQVGPSTL QSVVEKEKEG REEKGMRWRV SSRASPSLRC
RLRDRGDTEG KSRLIWDSGE FFVGISLRMT ATQDDLSGGL DANFSFSPEY KMLFFGLPTS
NASGLRLPDD AEYRLFNQFH LNQTLLSGTR MHGSVPLLYA IGRAPSRYGN KSLSGQRRCA
MGILWLNGSP LQVRTAVGDV GGETTLSFRS TAGATRVYLL PGPTAEDVLL QYYTLTGFPM
MPPLFALGYH HTHRGYGKMD EVLNVSAAFL QAEIPVDTLG MGSHYMNGKR IFTWNRTRFS
DPVRLQDELW RHGGRFMVLS TVPYVRVDPR FSIYIEGKRH EYFVTTQAES DEIFIGYSKS
GTNVWIDFLD SRARRWYGGL MKYKRFLGST NHTFFSLEEN EPFLRGGMQG TLPMEVGHRG
AVPHGVIHNM YGMLHAMAAY GGELRRTQFY RRPFLITQSY FAGTQRHAAV RLGYNVASWE
HLRSSIELCL AHSIAGISFV GADVGGFYFQ KVEDELLVRW YQLAVFYPLF RTDANEDAPF
REVWHLLPHV RARIRDAVHF RYALLPYLYT LFWKAHLDGE LIIRPLFFVY PQDALSYVEP
RMLGQWFFLG PHLFVAPVLT SVETGDALHT VQIPQEDLYN FWSGEFVAAG TTLRFSKNIS
YSHLPEEEIT PLFQRVGTIL PTFTNTSGMR STHDAANYTL TVTLPRLEPF FSEGSGGKGG
KSGESGISNQ ILAQGDLFVD DGSRHINYHG RNTTHHAFCA LALECVLFPR KGDLVLRWRA
ITNSSCCDVL HVVRSSMTSV TDGESFLLNR LRFMFATPKE KEHVTRVESL VDGQRLTFAP
SGSKPSLLEV SGVALPLLAE NCHGNDDDSR GSSQPTVEVH LKLNVSYGSW L
//
