ID K2NUV9_TRYCR Unreviewed; 765 AA.
AC K2NUV9;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN ORFNames=MOQ_001006 {ECO:0000313|EMBL:EKF38781.1};
OS Trypanosoma cruzi marinkellei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=85056 {ECO:0000313|EMBL:EKF38781.1, ECO:0000313|Proteomes:UP000007350};
RN [1] {ECO:0000313|EMBL:EKF38781.1, ECO:0000313|Proteomes:UP000007350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B7 {ECO:0000313|EMBL:EKF38781.1,
RC ECO:0000313|Proteomes:UP000007350};
RX PubMed=23035642; DOI=10.1186/1471-2164-13-531;
RA Franzen O., Talavera-Lopez C., Ochaya S., Butler C.E., Messenger L.A.,
RA Lewis M.D., Llewellyn M.S., Marinkelle C.J., Tyler K.M., Miles M.A.,
RA Andersson B.;
RT "Comparative genomic analysis of human infective Trypanosoma cruzi lineages
RT with the bat-restricted subspecies T. cruzi marinkellei.";
RL BMC Genomics 13:531-531(2012).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|RuleBase:RU363039}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF38781.1}.
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DR EMBL; AHKC01005002; EKF38781.1; -; Genomic_DNA.
DR AlphaFoldDB; K2NUV9; -.
DR EnsemblProtists; EKF38781; EKF38781; MOQ_001006.
DR OrthoDB; 166496at2759; -.
DR Proteomes; UP000007350; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07957; Anticodon_Ia_Met; 1.
DR CDD; cd00814; MetRS_core; 1.
DR Gene3D; 2.170.220.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR041872; Anticodon_Met.
DR InterPro; IPR014758; Met-tRNA_synth.
DR InterPro; IPR023457; Met-tRNA_synth_2.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR033911; MetRS_core.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR NCBIfam; TIGR00398; metG; 1.
DR PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR Pfam; PF19303; Anticodon_3; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR01041; TRNASYNTHMET.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363039};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363039};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363039};
KW Reference proteome {ECO:0000313|Proteomes:UP000007350}.
FT DOMAIN 235..609
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 621..761
FT /note="Methionyl-tRNA synthetase anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF19303"
SQ SEQUENCE 765 AA; 86106 MW; 2914F17DDF9ECD69 CRC64;
MSLKLFSEKA NTQALKALLC CHHVKRPVEL TLSGAYTSPV LHHPAFKQPI FSANEMARLI
LHDKWRDDSA GGSGGKKAGC YDGDWACVSL EEEAWLEWEA TTFTCAVHPL YTQRRVTPEA
AGAFEYLDKK IHENDCQGPC LAPVGEKGTS TKSSSFLVDC IIWCAVLPAL CEGGLLGEKE
REQVPHLLKW FESFQSAREE HIAGAVESLA VQEFADFLRA PRVYKISPKL NKVFFITTPI
YYVNAAPHIG HVYSTLIADV IGRYHTIKGE RAFAMSGTDE HGQKVAGAAK QKGMNPYDFT
YQVSREFIDC FDQMGYHMDY FIRTTNESHK KVVHELWSKL EAKGDIYLGR YEGWYSVSDE
SFLTAQNVTD GVDKDGKPCK VSLESGHVVT WLAEDNYMFR LSAFRERLLE WYNNNPGCIV
PEFRRREVIR TVEKGLNDLS VSRTREAVQD WAIPVPGNPN HCIYVWLDAL SNYYTGSRLR
LGKSGEELEL VEDYRVLERF PADIHVIGKD ILKFHAIYWP AFLISAGLPL PKTIVAHGWW
TKDRKKISKS LGNVFDPVEK AREFGFDALK YFLLRETGFS DDGDYSDRNM IARLNGELAD
TLGNLVMRCT STKINVNREW PTPDTYNAND EALIQRIKDL PGVVDHFFLI PDVQKALAAV
FDVLRAINSY VTENAPWKLV KTDPDRLRTV LYITMEGIRL ATLMLSPVLS QKAPVIFDML
GVPEANRVGV ENFEFGVVPA GTPIGEGAEG EVLFPKISLD KAQSA
//
