ID K2PK16_9LACT Unreviewed; 435 AA.
AC K2PK16;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Xanthine-uracil permease {ECO:0000313|EMBL:EKF50534.1};
GN ORFNames=C426_2109 {ECO:0000313|EMBL:EKF50534.1};
OS Lactococcus garvieae DCC43.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=1231377 {ECO:0000313|EMBL:EKF50534.1, ECO:0000313|Proteomes:UP000006787};
RN [1] {ECO:0000313|EMBL:EKF50534.1, ECO:0000313|Proteomes:UP000006787}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DCC43 {ECO:0000313|EMBL:EKF50534.1,
RC ECO:0000313|Proteomes:UP000006787};
RX PubMed=23209230; DOI=10.1128/JB.01864-12;
RA Gabrielsen C., Brede D.A., Hernandez P.E., Nes I.F., Diep D.B.;
RT "Genome Sequence of the Bacteriocin-Producing Strain Lactococcus garvieae
RT DCC43.";
RL J. Bacteriol. 194:6976-6977(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKF50534.1}.
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DR EMBL; AMQS01000041; EKF50534.1; -; Genomic_DNA.
DR RefSeq; WP_003136744.1; NZ_AMQS01000041.1.
DR AlphaFoldDB; K2PK16; -.
DR PATRIC; fig|1231377.3.peg.2091; -.
DR eggNOG; COG2233; Bacteria.
DR Proteomes; UP000006787; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR InterPro; IPR017588; UacT-like.
DR InterPro; IPR006042; Xan_ur_permease.
DR NCBIfam; TIGR00801; ncs2; 1.
DR NCBIfam; NF037981; NCS2_1; 1.
DR NCBIfam; TIGR03173; pbuX; 1.
DR PANTHER; PTHR42810; PURINE PERMEASE C1399.01C-RELATED; 1.
DR PANTHER; PTHR42810:SF4; URIC ACID TRANSPORTER UACT; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
DR PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 435 AA; 46185 MW; BB25F51907BAFDC0 CRC64;
MFNTKRQANG QAAVLGLQHL LAMYSGSILV PIMIASALNY SALQLTYLIS TDIFMCGLAT
LLQLKMTKNF GIGLPVVLGV AFQSVAPLII IGQKHGDGAM FGALIASGVF VIAIAGIFSK
IRKFFPPLVT GSVITTIGLT LIPVAVGNMG NNEAAPTTNS LLLAAFTILV ILLVNIFAKG
FIRSIAILIG LVAGTLLAAS LHMVDFSAIN QAPWAHLPVP FRMAMPRFYF VDCLMMIIIA
IVSMVESTGV YLALSDLTGE ELSEKRLRNG YRSEGLAVLL GGIFNTFPYT GFSQNVGLVQ
LSGIKSRKPI YFTAGFLIVL GLIPKFAAIA QLIPVPVLGG AMLIMFGMVA MQGVNMLGTV
DYKDNQNLLI VAISVGMGVG FNSSNLFVSL PNWAQIFLSN GIVVSTVSAI LLNLILNSKS
RTKVAMNSSE VKANS
//
