ID K2S5N0_MACPH Unreviewed; 250 AA.
AC K2S5N0;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=MPH_10890 {ECO:0000313|EMBL:EKG11995.1};
OS Macrophomina phaseolina (strain MS6) (Charcoal rot fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetes incertae sedis; Botryosphaeriales; Botryosphaeriaceae;
OC Macrophomina.
OX NCBI_TaxID=1126212 {ECO:0000313|EMBL:EKG11995.1, ECO:0000313|Proteomes:UP000007129};
RN [1] {ECO:0000313|EMBL:EKG11995.1, ECO:0000313|Proteomes:UP000007129}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MS6 {ECO:0000313|EMBL:EKG11995.1,
RC ECO:0000313|Proteomes:UP000007129};
RX PubMed=22992219; DOI=10.1186/1471-2164-13-493;
RA Islam M.S., Haque M.S., Islam M.M., Emdad E.M., Halim A., Hossen Q.M.M.,
RA Hossain M.Z., Ahmed B., Rahim S., Rahman M.S., Alam M.M., Hou S., Wan X.,
RA Saito J.A., Alam M.;
RT "Tools to kill: Genome of one of the most destructive plant pathogenic
RT fungi Macrophomina phaseolina.";
RL BMC Genomics 13:493-493(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKG11995.1}.
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DR EMBL; AHHD01000462; EKG11995.1; -; Genomic_DNA.
DR AlphaFoldDB; K2S5N0; -.
DR STRING; 1126212.K2S5N0; -.
DR VEuPathDB; FungiDB:MPH_10890; -.
DR eggNOG; ENOG502QTD3; Eukaryota.
DR HOGENOM; CLU_070319_0_0_1; -.
DR InParanoid; K2S5N0; -.
DR OrthoDB; 2049468at2759; -.
DR Proteomes; UP000007129; Unassembled WGS sequence.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF22; DJ-1_PFPI DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007129}.
FT DOMAIN 31..245
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 250 AA; 27784 MW; 9D4E180D0EC4A2A8 CRC64;
MVDKKVLIVV SDADSFPLKK SDGEVVQQPS GFFLMELAKP LDRLLNAGYE VTFASPEGRE
PTPDPNSESL LAFAGNFYER QRENELLERM KRENGFAAPR RFADISDDEC RQYAGVFIPG
GHAPLQDLGD NPELGRILSH FHEARKPTAA ICHGPHAFLS TKYGPKKEFA YKGYKITSWS
DAEEKFMETA MFRGEVEKVE SKLRENGAEM VENASTKVGT ITVDREVVSG ANPMAAATLG
DKFLEMLESK
//
