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Database: UniProt
Entry: K3V8S9_FUSPC
LinkDB: K3V8S9_FUSPC
Original site: K3V8S9_FUSPC 
ID   K3V8S9_FUSPC            Unreviewed;       309 AA.
AC   K3V8S9;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=L-lactate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=FPSE_09737 {ECO:0000313|EMBL:EKJ70077.1};
OS   Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS   fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX   NCBI_TaxID=1028729 {ECO:0000313|EMBL:EKJ70077.1};
RN   [1] {ECO:0000313|EMBL:EKJ70077.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CS3096 {ECO:0000313|EMBL:EKJ70077.1};
RX   PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA   Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA   Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT   "Comparative pathogenomics reveals horizontally acquired novel virulence
RT   genes in fungi infecting cereal hosts.";
RL   PLoS Pathog. 8:E1002952-E1002952(2012).
RN   [2] {ECO:0000313|EMBL:EKJ70077.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CS3096 {ECO:0000313|EMBL:EKJ70077.1};
RA   Gardiner D.M., Kazan K., Chakraborty S., Manners J.M.;
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily.
CC       {ECO:0000256|RuleBase:RU003369}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EKJ70077.1}.
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DR   EMBL; AFNW01000314; EKJ70077.1; -; Genomic_DNA.
DR   RefSeq; XP_009261129.1; XM_009262854.1.
DR   AlphaFoldDB; K3V8S9; -.
DR   EnsemblFungi; EKJ70077; EKJ70077; FPSE_09737.
DR   GeneID; 20368354; -.
DR   KEGG; fpu:FPSE_09737; -.
DR   eggNOG; KOG1495; Eukaryota.
DR   HOGENOM; CLU_045401_1_2_1; -.
DR   OrthoDB; 5344346at2759; -.
DR   Proteomes; UP000007978; Chromosome 1.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF16; L-LACTATE DEHYDROGENASE; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   PIRSF; PIRSF000102; Lac_mal_DH; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|PIRSR:PIRSR000102-3};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU003369}.
FT   DOMAIN          6..144
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          147..304
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
FT   ACT_SITE        177
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-1"
FT   BINDING         11..16
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         36
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
FT   BINDING         97
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000102-3"
SQ   SEQUENCE   309 AA;  33145 MW;  1B493BAED3BAA09B CRC64;
     MSSASRVAIV GVGEVGGAVA YNLTLNSMAS ELLLVDLDPS VRNAQIEDLS DVTYSTNSST
     RVRSATYHEA AQCDLVVITA ASKHMLGQTT IDYTSRNTSM LRGVMEAMKP FRADTVLLIV
     ADPVDLLTSL AKQMSGLPES QVIGTGTALD TYRLRGMVAS RALVSPYTVD AFVVGRHGEE
     QVVAWSSATI GAVPIQDVKM LEASDRSRIE LICKHRSNLI ILGKGSAPFG IASVVANLCC
     SVILDKHEIY PVSYFQEEHG CCLSLPAVIG RKGILNSVPL AMNEDESAAV KLSGKLLKAS
     VESIQRDWW
//
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