ID K3VFI5_FUSPC Unreviewed; 226 AA.
AC K3VFI5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=D-lactate dehydratase {ECO:0000256|ARBA:ARBA00013134};
DE EC=4.2.1.130 {ECO:0000256|ARBA:ARBA00013134};
GN ORFNames=FPSE_07124 {ECO:0000313|EMBL:EKJ72724.1};
OS Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=1028729 {ECO:0000313|EMBL:EKJ72724.1, ECO:0000313|Proteomes:UP000007978};
RN [1] {ECO:0000313|EMBL:EKJ72724.1, ECO:0000313|Proteomes:UP000007978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS3096 {ECO:0000313|EMBL:EKJ72724.1,
RC ECO:0000313|Proteomes:UP000007978};
RX PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT "Comparative pathogenomics reveals horizontally acquired novel virulence
RT genes in fungi infecting cereal hosts.";
RL PLoS Pathog. 8:E1002952-E1002952(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + methylglyoxal = (R)-lactate + H(+);
CC Xref=Rhea:RHEA:27754, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16004, ChEBI:CHEBI:17158; EC=4.2.1.130;
CC Evidence={ECO:0000256|ARBA:ARBA00001524};
CC -!- SIMILARITY: Belongs to the peptidase C56 family. HSP31-like subfamily.
CC {ECO:0000256|ARBA:ARBA00038493}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKJ72724.1}.
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DR EMBL; AFNW01000190; EKJ72724.1; -; Genomic_DNA.
DR RefSeq; XP_009258517.1; XM_009260242.1.
DR AlphaFoldDB; K3VFI5; -.
DR EnsemblFungi; EKJ72724; EKJ72724; FPSE_07124.
DR GeneID; 20365742; -.
DR KEGG; fpu:FPSE_07124; -.
DR eggNOG; ENOG502RZ3Y; Eukaryota.
DR HOGENOM; CLU_070319_2_0_1; -.
DR OrthoDB; 4342at2759; -.
DR Proteomes; UP000007978; Chromosome 4.
DR GO; GO:0019172; F:glyoxalase III activity; IEA:UniProt.
DR CDD; cd03141; GATase1_Hsp31_like; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR002818; DJ-1/PfpI.
DR PANTHER; PTHR48094:SF11; GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED; 1.
DR PANTHER; PTHR48094; PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED; 1.
DR Pfam; PF01965; DJ-1_PfpI; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007978};
KW Stress response {ECO:0000256|ARBA:ARBA00023016}.
FT DOMAIN 27..222
FT /note="DJ-1/PfpI"
FT /evidence="ECO:0000259|Pfam:PF01965"
SQ SEQUENCE 226 AA; 24408 MW; 797A17FF2D07C3B6 CRC64;
MAPKVLVVLT SQSKMNNGNP TGWYLPELAH PYYDLVNAGV EITVASPAGG EAPLDQGSVQ
MFKEDEESVK FLNEKKQVWE QTTPLKEFLG KSSEFDAIFY PGGHGPMFDL VNDETSIKLI
EEFYKAGKPV ASVCHGPIVF TQVKIDGKPL LEGREATGFS NSEEDAVGLT SAMPVLLEDE
IKRVGGKYVK ADDWAEKLVV DGQLITGQNP ASAHVVGKAI LKAIGA
//
