ID K3VLQ2_FUSPC Unreviewed; 1034 AA.
AC K3VLQ2;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=FPSE_04202 {ECO:0000313|EMBL:EKJ75559.1};
OS Fusarium pseudograminearum (strain CS3096) (Wheat and barley crown-rot
OS fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=1028729 {ECO:0000313|EMBL:EKJ75559.1, ECO:0000313|Proteomes:UP000007978};
RN [1] {ECO:0000313|EMBL:EKJ75559.1, ECO:0000313|Proteomes:UP000007978}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CS3096 {ECO:0000313|EMBL:EKJ75559.1,
RC ECO:0000313|Proteomes:UP000007978};
RX PubMed=23028337; DOI=10.1371/journal.ppat.1002952;
RA Gardiner D.M., McDonald M.C., Covarelli L., Solomon P.S., Rusu A.G.,
RA Marshall M., Kazan K., Chakraborty S., McDonald B.A., Manners J.M.;
RT "Comparative pathogenomics reveals horizontally acquired novel virulence
RT genes in fungi infecting cereal hosts.";
RL PLoS Pathog. 8:E1002952-E1002952(2012).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EKJ75559.1}.
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DR EMBL; AFNW01000084; EKJ75559.1; -; Genomic_DNA.
DR RefSeq; XP_009255595.1; XM_009257320.1.
DR AlphaFoldDB; K3VLQ2; -.
DR EnsemblFungi; EKJ75559; EKJ75559; FPSE_04202.
DR GeneID; 20362820; -.
DR KEGG; fpu:FPSE_04202; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_0_0_1; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000007978; Chromosome 3.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IEA:InterPro.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000007978};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 675..755
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 337..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..891
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..914
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..976
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 993..1034
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1034 AA; 117632 MW; 1989DEE78920E120 CRC64;
MALSHVFFAS TQYIIIPQSD TFRFPVDVHL LGIEIRTVFS NLMSAEGGIY NASDHYHHRN
SIRCLSLSHE VMHVHQQEQS NRHVNIQSYA LNDWCLLQLL KIVPGDSPEA FDRLFLRCRT
EDDGQMSKTG QERASLHTSD SKLDLKHLIQ YPLSIAESRL ANEREDQGHV RVLIRFPGLD
HNLMVPVSNR YSAQQSKACN FSSIDTVSRP PSTIINCTRN AHLFVATMEK SQDFKSLQES
VQKSLVSTTK TVNRIAAEDL SFQRTVNPNV GQQLDDRTSR ILELSTRLLQ STGKACGVKA
PKLEDVEDIE MKWRGVVDVV DSSLEKADTA LDEYTGLVKR KEPPASDSNQ AKKPKSTTKV
IRNANISKPQ LQFERKPDNF APPPWKPILK AKPHASVSLK ESLNIVPNEA GTPQYQHPYE
HEIVRMAYPK RVSREAEPIM YQPVDTTEAT YVDTYEGVLE MLGELMKAKE IAVDLEHHDF
RSYVGLVSLM QISTREKDWI VDTLQPWRHK LEVLNQVFTN PKIVKVFHGA YMDIIWLQRD
LGLYVNGLFD TFFACGQLNY PAKSLAYLLS KFVDFDADKK YQLADWRLRP LPQEMLYYAR
SDTHYLLYIY DRVRNELVAA SDKTDADKDL IGRALEKSRE QSLSRYEHPD YDQETGEGSR
GWSSYIFKNS HMAFDSEQFS VFRALWKWRD DTARKEDEST NFVLGNRDIS EIARINPPDA
KALHSLLPLN ASLARSRFNE IWGYIKESKA KGGRSLLHFF TSMAPDSLMR NGVPIAARKT
TRLPDLDGEV TVSRLTRSQL FGDMPISTQW DASTRRPETE EDLIPFPWQK FVEQGTIEGD
VQHDTVTDPA VVPAQPNHVE NAGGSAQVEE DDEEFTLKRG QKRKSEAVEE SDSSEGGSES
SDSESDEEMQ DDNGVIAIED GSSGKAESRN ARRKQRKAEE KKAKEEQLQR QEAKKARKAQ
KKQKKEDDKV KKFDAVPFDY SKATSVVNTK REPNTDVKGK KRVFDPYSKS ADTDIKGARK
APPVRGERSA TFKK
//
