ID K3W466_SACES Unreviewed; 232 AA.
AC K3W466;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=UDP-N-acetylglucosamine acyltransferase {ECO:0000313|EMBL:CCH27477.1};
GN Name=lpxA {ECO:0000313|EMBL:CCH27477.1};
GN OrderedLocusNames=BN6_01440 {ECO:0000313|EMBL:CCH27477.1};
OS Saccharothrix espanaensis (strain ATCC 51144 / DSM 44229 / JCM 9112 / NBRC
OS 15066 / NRRL 15764).
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1179773 {ECO:0000313|EMBL:CCH27477.1, ECO:0000313|Proteomes:UP000006281};
RN [1] {ECO:0000313|EMBL:CCH27477.1, ECO:0000313|Proteomes:UP000006281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51144 / DSM 44229 / JCM 9112 / NBRC 15066 / NRRL 15764
RC {ECO:0000313|Proteomes:UP000006281};
RX PubMed=22958348; DOI=10.1186/1471-2164-13-465;
RA Strobel T., Al-Dilaimi A., Blom J., Gessner A., Kalinowski J.,
RA Luzhetska M., Puhler A., Szczepanowski R., Bechthold A., Ruckert C.;
RT "Complete genome sequence of Saccharothrix espanaensis DSM 44229T and
RT comparison to the other completely sequenced Pseudonocardiaceae.";
RL BMC Genomics 13:465-465(2012).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE804045; CCH27477.1; -; Genomic_DNA.
DR RefSeq; WP_015097591.1; NC_019673.1.
DR AlphaFoldDB; K3W466; -.
DR STRING; 1179773.BN6_01440; -.
DR KEGG; sesp:BN6_01440; -.
DR PATRIC; fig|1179773.3.peg.145; -.
DR eggNOG; COG1043; Bacteria.
DR HOGENOM; CLU_061249_0_0_11; -.
DR OrthoDB; 2643438at2; -.
DR BioCyc; SESP1179773:BN6_RS00705-MONOMER; -.
DR Proteomes; UP000006281; Chromosome.
DR GO; GO:0008780; F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity; IEA:InterPro.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 1.
DR InterPro; IPR029098; Acetyltransf_C.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR010137; Lipid_A_LpxA.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR PANTHER; PTHR43480; ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR43480:SF1; ACYL-[ACYL-CARRIER-PROTEIN]--UDP-N-ACETYLGLUCOSAMINE O-ACYLTRANSFERASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF13720; Acetyltransf_11; 1.
DR Pfam; PF00132; Hexapep; 1.
DR SUPFAM; SSF51161; Trimeric LpxA-like enzymes; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:CCH27477.1};
KW Lipid A biosynthesis {ECO:0000256|ARBA:ARBA00022556};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000006281};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CCH27477.1}.
FT DOMAIN 167..199
FT /note="UDP N-acetylglucosamine O-acyltransferase C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF13720"
SQ SEQUENCE 232 AA; 23898 MW; 8F8875FFE336EE98 CRC64;
MANRIHQTAI IGAEVELGDD NVIGPYTVIA GPARIGDGNY IGPHVSIGGP AEYLGADHLA
GWDGEVGGPG VVIGDRNRIR EFVTVNQGVT EATAVGDDCY LMGRAHLAHD VRLDDGVIVT
SAVQIAGHCH VWSGANVGLG TVVHQRTTIG PGAMVGMGSA VRKEVGAFTI TVGNPARTTG
VNTVGLQRRG CTEESIAGLT GFLTGKDPAV PGDLPEELAA LLKAWAERGS QH
//
