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Database: UniProt
Entry: K3W4N7_MOUSE
LinkDB: K3W4N7_MOUSE
Original site: K3W4N7_MOUSE 
ID   K3W4N7_MOUSE            Unreviewed;      2020 AA.
AC   K3W4N7;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   05-JUL-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Scn5a {ECO:0000313|Ensembl:ENSMUSP00000066228,
GN   ECO:0000313|MGI:MGI:98251};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000066228, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000066228, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000066228,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000213|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
RN   [3] {ECO:0000313|Ensembl:ENSMUSP00000066228}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000066228};
RG   Ensembl;
RL   Submitted (OCT-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24129315}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24129315;
RA   Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
RA   Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
RA   Vemulapalli V., Bedford M.T., Comb M.J.;
RT   "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT   methylation.";
RL   Mol. Cell. Proteomics 13:372-387(2014).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000066228}.
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DR   EMBL; AC121922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC171201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001240789.1; NM_001253860.1.
DR   RefSeq; XP_006512060.1; XM_006511997.1.
DR   UniGene; Mm.103584; -.
DR   ProteinModelPortal; K3W4N7; -.
DR   SMR; K3W4N7; -.
DR   PaxDb; K3W4N7; -.
DR   PeptideAtlas; K3W4N7; -.
DR   Ensembl; ENSMUST00000065196; ENSMUSP00000066228; ENSMUSG00000032511.
DR   GeneID; 20271; -.
DR   KEGG; mmu:20271; -.
DR   UCSC; uc009sbe.2; mouse.
DR   CTD; 6331; -.
DR   MGI; MGI:98251; Scn5a.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   KO; K04838; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   Proteomes; UP000000589; Chromosome 9.
DR   Bgee; ENSMUSG00000032511; -.
DR   ExpressionAtlas; K3W4N7; baseline and differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:K3W4N7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    149       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    388    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    718    736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    748    769       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    781    798       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    861       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    881    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    941       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1208   1227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1248   1264       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1276   1297       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1325   1351       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1532   1550       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1562   1580       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1592   1612       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1649   1677       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      478    667       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      718    945       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      955   1203       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1207   1482       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    451       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2020 AA;  227705 MW;  A8377632C74EB7DA CRC64;
     MANFLLPRGT SSFRRFTRES LAAIEKRMAE KQARGSATSQ ESREGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYVLSPFHPV
     RRAAVKILVH SLFSMLIMCT ILTNCVFMAQ HDPPPWTKYV EYTFTAIYTF ESLVKILARG
     FCLHAFTFLR DPWNWLDFSV IVMAYTTEFV DLGNVSALRT FRVLRALKTI SVISGLKTIV
     GALIQSVKKL ADVMVLTVFC LSVFALIGLQ LFMGNLRHKC VRNFTELNGT NGSVEADGIV
     WNSLDVYLND PANYLLKNGT TDVLLCGNSS DAGTCPEGYR CLKAGENPDH GYTSFDSFAW
     AFLALFRLMT QDCWERLYQQ TLRSAGKIYM IFFMLVIFLG SFYLVNLILA VVAMAYEEQN
     QATIAETEEK EKRFQEAMEM LKKEHEALTI RGVDTVSRSS LEMSPLAPVT NHERRSKRRK
     RLSSGTEDGG DDRLPKSDSE DGPRALNQLS LTHGLSRTSM RPRSSRGSIF TFRRRDQGSE
     ADFADDENST AGESESHRTS LLVPWPLRRP STQGQPGFGT SAPGHVLNGK RNSTVDCNGV
     VSLLGAGDAE ATSPGSHLLR PIVLDRPPDT TTPSEEPGGP QMLTPQAPCA DGFEEPGARQ
     RALSAVSVLT SALEELEESH RKCPPCWNRF AQHYLIWECC PLWMSIKQKV KFVVMDPFAD
     LTITMCIVLN TLFMALEHYN MTAEFEEMLQ VGNLVFTGIF TAEMTFKIIA LDPYYYFQQG
     WNIFDSIIVI LSLMELGLSR MGNLSVLRSF RLLRVFKLAK SWPTLNTLIK IIGNSVGALG
     NLTLVLAIIV FIFAVVGMQL FGKNYSELRH RISDSGLLPR WHMMDFFHAF LIIFRILCGE
     WIETMWDCME VSGQSLCLLV FLLVMVIGNL VVLNLFLALL LSSFSADNLT APDEDGEMNN
     LQLALARIQR GLRFVKRTTW DFCCGLLRRR PKKPAALATH SQLPSCIAAP RSPPPPEVEK
     APPARKETRF EEDKRPGQGT PGDTEPVCVP IAVAESDTDD QEEDEENSLG TEEEESSKQQ
     ESQVVSGGHE PPQEPRAWSQ VSETTSSEAE ASTSQADWQQ EREAEPRAPG CGETPEDSYS
     EGSTADMTNT ADLLEQIPDL GEDVKDPEDC FTEGCVRRCP CCMVDTTQAP GKVWWRLRKT
     CYRIVEHSWF ETFIIFMILL SSGALAFEDI YLEERKTIKV LLEYADKMFT YVFVLEMLLK
     WVAYGFKKYF TNAWCWLDFL IVDVSLVSLV ANTLGFAEMG PIKSLRTLRA LRPLRALSRF
     EGMRVVVNAL VGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFGRCINQT EGDLPLNYTI
     VNNKSECESF NVTGELYWTK VKVNFDNVGA GYLALLQVAT FKGWMDIMYA AVDSRGYEEQ
     PQWEDNLYMY IYFVVFIIFG SFFTLNLFIG VIIDNFNQQK KKLGGQDIFM TEEQKKYYNA
     MKKLGSKKPQ KPIPRPLNKY QGFIFDIVTK QAFDVTIMFL ICLNMVTMMV ETDDQSPEKV
     NILAKINLLF VAIFTGECIV KMAALRHYYF TNSWNIFDFV VVILSIVGTV LSDIIQKYFF
     SPTLFRVIRL ARIGRILRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYSIFGMA
     NFAYVKWEAG IDDMFNFQTF ANSMLCLFQI TTSAGWDGLL SPILNTGPPY CDPNLPNSNG
     SRGNCGSPAV GILFFTTYII ISFLIVVNMY IAIILENFSV ATEESTEPLS EDDFDMFYEI
     WEKFDPEATQ FIEYLALSDF ADALSEPLRI AKPNQISLIN MDLPMVSGDR IHCMDILFAF
     TKRVLGESGE MDALKIQMEE KFMAANPSKI SYEPITTTLR RKHEEVSATV IQRAFRRHLL
     QRSVKHASFL FRQQAGSSGL SDEDAPEREG LIAYMMNENF SRRSGPLSSS SISSTSFPPS
     YDSVTRATSD NLPVRASDYS RSEDLADFPP SPDRDRESIV
//
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