ID K3XF55_SETIT Unreviewed; 695 AA.
AC K3XF55;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Peptidase M3A/M3B catalytic domain-containing protein {ECO:0000259|Pfam:PF01432};
GN Name=101785951 {ECO:0000313|EnsemblPlants:KQL08192};
GN ORFNames=SETIT_5G417900v2 {ECO:0000313|EMBL:RCV28619.1};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQL08192, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EMBL:RCV28619.1, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQL08192,
RC ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC {ECO:0000313|EMBL:RCV28619.1};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EMBL:RCV28619.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Yugu1 {ECO:0000313|EMBL:RCV28619.1};
RA Noorani M.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQL08192}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQL08192};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|RuleBase:RU003435};
CC Note=Binds 1 zinc ion. {ECO:0000256|RuleBase:RU003435};
CC -!- SIMILARITY: Belongs to the peptidase M3 family.
CC {ECO:0000256|ARBA:ARBA00006040, ECO:0000256|RuleBase:RU003435}.
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DR EMBL; AGNK02003421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CM003532; RCV28619.1; -; Genomic_DNA.
DR RefSeq; XP_004970954.1; XM_004970897.2.
DR AlphaFoldDB; K3XF55; -.
DR STRING; 4555.K3XF55; -.
DR MEROPS; M03.A03; -.
DR EnsemblPlants; KQL08192; KQL08192; SETIT_000522mg.
DR GeneID; 101785951; -.
DR Gramene; KQL08192; KQL08192; SETIT_000522mg.
DR KEGG; sita:101785951; -.
DR eggNOG; KOG2089; Eukaryota.
DR HOGENOM; CLU_001805_2_1_1; -.
DR InParanoid; K3XF55; -.
DR OMA; MYTREGK; -.
DR OrthoDB; 735202at2759; -.
DR Proteomes; UP000004995; Chromosome V.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0006518; P:peptide metabolic process; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd06455; M3A_TOP; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 1.10.1370.10; Neurolysin, domain 3; 1.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR024077; Neurolysin/TOP_dom2.
DR InterPro; IPR024080; Neurolysin/TOP_N.
DR InterPro; IPR045090; Pept_M3A_M3B.
DR InterPro; IPR001567; Pept_M3A_M3B_dom.
DR PANTHER; PTHR11804; PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED; 1.
DR PANTHER; PTHR11804:SF82; THIMET OLIGOPEPTIDASE-RELATED; 1.
DR Pfam; PF01432; Peptidase_M3; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU003435};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU003435};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000256|RuleBase:RU003435};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU003435};
KW Reference proteome {ECO:0000313|Proteomes:UP000004995};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003435}.
FT DOMAIN 248..689
FT /note="Peptidase M3A/M3B catalytic"
FT /evidence="ECO:0000259|Pfam:PF01432"
SQ SEQUENCE 695 AA; 78712 MW; 735CCFF05A814C8D CRC64;
MEPRRRERRV IAVAGAAALV AVGLNIAFSA VAAHRRRKRR ELPGFTARVN LSAAEIKRLA
DRIIAKAKET YDSVAAVPLD KVSFANVIAP LAELDALQFP LVQACVLPRM VSPSEDVRKA
SAEAENRLDS HFVMCRQRED VYRVIKAFAV KGERIGPEAT RFLQCLVKEF ERNGVKLSQH
KRKEMEKLKS HIDELNLKYL QNLNDFTKFL LLSEDELAGM PFEFLKDLEK ADGKLKVPLS
SYHVTPILEH CKVGSTRKQI AVAYGQKGGK DNLGILENLV QLRHKFARLL GYGNYADFAI
EPRMPRTSRK VLEFLEEMSE QLSDVANREL SILKDLKMKE EGNAQFGMED LLYYVKRAEE
FKVDLDIGEI KKYFPVSLVV SGMLKMYQDL FALRFDEIKD AEVWHDTVRV FSVWDASSSD
LLGYFFLDIF AREGKYAHTC VVTLQNGCLC SNGTRKVPAA VLLSQCPKEF DGNSALLRFP
EVVRLFHEFS HVVHHISNRA TFSRFSALRL EGDFAEIPSL LLENWCFESI SLKMMSGFHQ
DITRSVTSEA CQSLKRRRDL FAGLKMKQEI LLCLVDQIIH SSENVDIDDL IKELHPKVML
GIPLLEGTSP ASCFPRIAVG YDAVCYSYIW SEVFAADLFV SKFKDDLLNQ HAGLRFRNKV
LAPGGSKDPL EIITDYLGRE PSLQPFIQSR TGNSL
//
