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Database: UniProt
Entry: K3ZH71_SETIT
LinkDB: K3ZH71_SETIT
Original site: K3ZH71_SETIT 
ID   K3ZH71_SETIT            Unreviewed;       951 AA.
AC   K3ZH71;
DT   28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT   28-NOV-2012, sequence version 1.
DT   28-MAR-2018, entry version 33.
DE   RecName: Full=Non-lysosomal glucosylceramidase {ECO:0000256|PIRNR:PIRNR028944};
DE            Short=NLGase {ECO:0000256|PIRNR:PIRNR028944};
DE            EC=3.2.1.45 {ECO:0000256|PIRNR:PIRNR028944};
GN   Name=LOC101782092 {ECO:0000313|EnsemblPlants:Si025923m};
GN   ORFNames=SETIT_025923mg {ECO:0000313|EMBL:KQK94115.1};
OS   Setaria italica (Foxtail millet) (Panicum italicum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae;
OC   PACMAD clade; Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX   NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:Si025923m};
RN   [1] {ECO:0000313|EMBL:KQK94115.1, ECO:0000313|EnsemblPlants:Si025923m, ECO:0000313|Proteomes:UP000004995}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:Si025923m,
RC   ECO:0000313|Proteomes:UP000004995}, and Yugu1
RC   {ECO:0000313|EMBL:KQK94115.1};
RX   PubMed=22580951; DOI=10.1038/nbt.2196;
RA   Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA   Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J.,
RA   Jenkins J., Barry K., Lindquist E., Hellsten U., Deshpande S.,
RA   Wang X., Wu X., Mitros T., Triplett J., Yang X., Ye C.Y.,
RA   Mauro-Herrera M., Wang L., Li P., Sharma M., Sharma R., Ronald P.C.,
RA   Panaud O., Kellogg E.A., Brutnell T.P., Doust A.N., Tuskan G.A.,
RA   Rokhsar D., Devos K.M.;
RT   "Reference genome sequence of the model plant Setaria.";
RL   Nat. Biotechnol. 30:555-561(2012).
RN   [2] {ECO:0000313|EnsemblPlants:Si025923m}
RP   IDENTIFICATION.
RC   STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:Si025923m};
RG   EnsemblPlants;
RL   Submitted (OCT-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:KQK94115.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Yugu1 {ECO:0000313|EMBL:KQK94115.1};
RA   Cajimat M.N.B., Milazzo M.L., Fulhorst C.F.;
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-lysosomal glucosylceramidase that catalyzes the
CC       conversion of glucosylceramide to free glucose and ceramide.
CC       {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- CATALYTIC ACTIVITY: D-glucosyl-N-acylsphingosine + H(2)O = D-
CC       glucose + N-acylsphingosine. {ECO:0000256|PIRNR:PIRNR028944}.
CC   -!- SIMILARITY: Belongs to the non-lysosomal glucosylceramidase
CC       family. {ECO:0000256|PIRNR:PIRNR028944}.
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DR   EMBL; CM003535; KQK94115.1; -; Genomic_DNA.
DR   RefSeq; XP_004979008.1; XM_004978951.3.
DR   STRING; 4555.Si025923m; -.
DR   EnsemblPlants; Si025923m; Si025923m; Si025923m.g.
DR   GeneID; 101782092; -.
DR   Gramene; Si025923m; Si025923m; Si025923m.g.
DR   KEGG; sita:101782092; -.
DR   eggNOG; KOG2119; Eukaryota.
DR   eggNOG; COG4354; LUCA.
DR   InParanoid; K3ZH71; -.
DR   KO; K17108; -.
DR   OMA; HDYQDSS; -.
DR   OrthoDB; EOG09360216; -.
DR   Proteomes; UP000004995; Chromosome VIII.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004348; F:glucosylceramidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006680; P:glucosylceramide catabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR014551; B_Glucosidase_GBA2-typ.
DR   InterPro; IPR006775; GH116_catalytic.
DR   InterPro; IPR024462; GH116_N.
DR   Pfam; PF04685; DUF608; 1.
DR   Pfam; PF12215; Glyco_hydr_116N; 1.
DR   PIRSF; PIRSF028944; Beta_gluc_GBA2; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000004995};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR028944};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR028944};
KW   Lipid metabolism {ECO:0000256|PIRNR:PIRNR028944};
KW   Membrane {ECO:0000256|PIRNR:PIRNR028944};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT   DOMAIN       99    417       Glyco_hydr_116N. {ECO:0000259|Pfam:
FT                                PF12215}.
FT   DOMAIN      530    890       DUF608. {ECO:0000259|Pfam:PF04685}.
SQ   SEQUENCE   951 AA;  106764 MW;  D61058C64F14852D CRC64;
     MVENGTDEQP KGVSRNCPPA HMNGDEEKVY PGQLPVLTWE HKLTHVRHDL PSFRLTWRET
     RQLAGIGLRL GRHILEETSK GRVSVIDPMK KRIAKSGQGV PLGGIGAGSI GRSYTGDFQR
     WQLFPGTCED KPVLANQFSA FISHQDGRKY STVLHPGKPD LPKGSEISGI GSWDWNMSGQ
     HSTYHALYPR AWTVYDGEPD PELNIVCRQI SPIIPHNYQQ SSYPAAVFTF TVTNSGHTAA
     DVTLLFTWAN SVGGKSELTG YHSNSSMIEK DGVHGILLHH RTADGQPPVT FAIAAQEKED
     IHISECPCFL ISGNSDGFTA KDMWNSVKEH GSFDHLDPIK TSMCSKPGSS IGAAIAASLK
     IAPKATQDVS FSLAWACPEV KFSSGKTYHR RYTKFYGTDV DAAASLAHDA ILEHTTWERQ
     IEDWQDPILQ DERFPAWYPV TLFNELYYLN AGGTIWTDGL PPIQSLTAIG GKKFSLDMLN
     DDDVNEMIQQ NNTASDILHR MASILERMHA SIASNSAIGT TLLHGEENIG QFLYLEGIEY
     YMWNTYDVHF YASFSLVMLF PKLQISVQRD FAAAVMMHDP EKLRILHDGK WAARKVLGAV
     PHDLGLYDPW FKVNAYTLYN TDRWKDLNPK FVLQVYRDVV ATGDKSFARA VWPSVYMAMA
     YMEQFDKDKD GMIENENFPD QTYDVWSMAG ISAYCGGLWV AALQAASALA REVGDEASEK
     LFWDKYEKAK SVYSKLWNGS YFNYDDGDNK VSTSIQADQL AGQWYAKACG LFPIVDKDKA
     QSALEKIYSF NVMKFKDGTR GAMNGMWPDG TLDMSAMQSR EIWPGVTYAL AATMIQEGMV
     EQGFKTAEGI YHAAWSPEGL GYSFQTPEAW NNDDEYRSLC YMRPLAIWAI QWALSNPKLH
     NTPQTDIAQD SFPKTQISYT RIAKLLQLPE DESSKSFVRV VYEIIQNRFW S
//
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