ID K4A6N1_SETIT Unreviewed; 678 AA.
AC K4A6N1;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN Name=101770158 {ECO:0000313|EnsemblPlants:KQK92501};
OS Setaria italica (Foxtail millet) (Panicum italicum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade;
OC Panicoideae; Panicodae; Paniceae; Cenchrinae; Setaria.
OX NCBI_TaxID=4555 {ECO:0000313|EnsemblPlants:KQK92501, ECO:0000313|Proteomes:UP000004995};
RN [1] {ECO:0000313|EnsemblPlants:KQK92501, ECO:0000313|Proteomes:UP000004995}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Yugu1 {ECO:0000313|EnsemblPlants:KQK92501,
RC ECO:0000313|Proteomes:UP000004995};
RX PubMed=22580951; DOI=10.1038/nbt.2196;
RA Bennetzen J.L., Schmutz J., Wang H., Percifield R., Hawkins J.,
RA Pontaroli A.C., Estep M., Feng L., Vaughn J.N., Grimwood J., Jenkins J.,
RA Barry K., Lindquist E., Hellsten U., Deshpande S., Wang X., Wu X.,
RA Mitros T., Triplett J., Yang X., Ye C.Y., Mauro-Herrera M., Wang L., Li P.,
RA Sharma M., Sharma R., Ronald P.C., Panaud O., Kellogg E.A., Brutnell T.P.,
RA Doust A.N., Tuskan G.A., Rokhsar D., Devos K.M.;
RT "Reference genome sequence of the model plant Setaria.";
RL Nat. Biotechnol. 30:555-561(2012).
RN [2] {ECO:0000313|EnsemblPlants:KQK92501}
RP IDENTIFICATION.
RC STRAIN=Yugu1 {ECO:0000313|EnsemblPlants:KQK92501};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
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DR EMBL; AGNK02006128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; K4A6N1; -.
DR EnsemblPlants; KQK92501; KQK92501; SETIT_034361mg.
DR Gramene; KQK92501; KQK92501; SETIT_034361mg.
DR Proteomes; UP000004995; Chromosome IX.
DR ExpressionAtlas; K4A6N1; baseline.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000004995}.
FT DOMAIN 315..395
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 640..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 678 AA; 76316 MW; 9ACA81D8ED2AEF61 CRC64;
MDGPEGVKGR EDAAPGREAG DPEEAGDGFQ LVSHDKKKKR ASGQEGGGSA GSGAFLGAGS
VRALTQDKGG APAPGTKAKV PFHDPTIPRP QEVYKIIVDN YKPFEHVWLE RSEDGTRCVH
PLVDLEHNQY RSFQGLTCLM QISTRTEDFI VDTLKLRIYI GLYLQEPFKD PTKRKVMHGA
DRDIMWLQRD FHIYICNLFD TGQASRVLQM ERNSLEYLLL RFCGVTAKKE YQNADWRSRP
LPDEMIKYAR EDTHYLLYIY DLMKQRLQRE STPENDLLLE VHKRSNEICL QFYEKELLTD
TSYLHIYGLQ EHELNSKQLA VVAALHGWRD RLARQEDEST GYVLPNKALI EIAKQMPTDT
GHLKRIVKSK YPFVERSLDE IAYTVWNALE YSYAFEGIAE QLKKERSEQL ALKSVQASDE
TTLLDVDSDK SNIGTADQSS VAPSSTANVS VASGSGAGFM NETAMIDSIH LDDNTRTTST
KNFKTLSGLT RPINKDVLSN NRYQQATQEL KRPTLGALGN SEPGRQTEIF GGFSKEQFQG
GSNVENFRSS VLPFQQFSDG VKHSAAIGPT ESFYPNTGMH SDNVWIQSTQ MNEAMQLSNA
TYYPQLPGYS TEVVGNHYEP EGMQMSSYLS GFEPTFQSIS QSTGTGLLPG RNKEGNFQNP
MRRQSYPPSS NRYDRPYQ
//
