ID K4DBD5_SOLLC Unreviewed; 390 AA.
AC K4DBD5;
DT 28-NOV-2012, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0000259|Pfam:PF00931};
OS Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC Solanum subgen. Lycopersicon.
OX NCBI_TaxID=4081 {ECO:0000313|EnsemblPlants:Solyc12g005970.1.1};
RN [1] {ECO:0000313|EnsemblPlants:Solyc12g005970.1.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc12g005970.1.1};
RX PubMed=22660326; DOI=10.1038/nature11119;
RG Tomato Genome Consortium;
RT "The tomato genome sequence provides insights into fleshy fruit
RT evolution.";
RL Nature 485:635-641(2012).
RN [2] {ECO:0000313|EnsemblPlants:Solyc12g005970.1.1}
RP IDENTIFICATION.
RC STRAIN=cv. Heinz 1706 {ECO:0000313|EnsemblPlants:Solyc12g005970.1.1};
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Confers resistance to late blight (Phytophthora infestans)
CC races carrying the avirulence gene Avr1. Resistance proteins guard the
CC plant against pathogens that contain an appropriate avirulence protein
CC via an indirect interaction with this avirulence protein. That triggers
CC a defense system including the hypersensitive response, which restricts
CC the pathogen growth. {ECO:0000256|ARBA:ARBA00002074}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
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DR AlphaFoldDB; K4DBD5; -.
DR PaxDb; 4081-Solyc12g005970-1-1; -.
DR EnsemblPlants; Solyc12g005970.1.1; Solyc12g005970.1.1; Solyc12g005970.1.
DR Gramene; Solyc12g005970.1.1; Solyc12g005970.1.1; Solyc12g005970.1.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_708633_0_0_1; -.
DR InParanoid; K4DBD5; -.
DR PhylomeDB; K4DBD5; -.
DR Proteomes; UP000004994; Chromosome 12.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038005; RX-like_CC.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1235; DISEASE RESISTANCE RPP13-LIKE PROTEIN 1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hypersensitive response {ECO:0000256|ARBA:ARBA00022667};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Plant defense {ECO:0000256|ARBA:ARBA00022667};
KW Reference proteome {ECO:0000313|Proteomes:UP000004994}.
FT DOMAIN 142..230
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 390 AA; 44986 MW; E5D9C499C071E6ED CRC64;
MQCNHPLLNN LKRKEQILSL SKRIIAFQEF LTDSETIKHR HERLKMLEGK IKEKTYQVED
IVDSKLRKYF VAKNANYRRK AFEVLCRRLQ VAIEEMEFIK KEVTKIKGDK ISTLKFHKQV
LPARHISTSS PDVQQKPVGF QEDLEKIIDR LRGGPSELDI ICIVGMAGIG KTTLAKRAYN
DISVVNRFDV RAWFPSEIMQ LVNLRYLALA TSSEFPPTVS QFWSLQTLIL HVYSRNSTLP
REIWKMPNLR HLHIKPSICL PSQTNEERNG YNSLVLNNLQ TLTNITLADC TTDVFSSTPK
LKKLGICETV EYTYPVQIPW SDFLYTSENL WPYCSDTISD LWSDCLRNLA LLPQLEALKI
VGLRAPVQVP KLAFHLDEQS GNKLKRDSVL
//
