ID K4EJR1_9RODE Unreviewed; 168 AA.
AC K4EJR1;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Alpha-2B adrenergic receptor {ECO:0000256|ARBA:ARBA00019305};
DE AltName: Full=Alpha-2B adrenoreceptor {ECO:0000256|ARBA:ARBA00031735};
DE Flags: Fragment;
GN Name=A2AB {ECO:0000313|EMBL:AEK81884.1};
OS Scarturus hotsoni (Hotson's jerboa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Dipodoidea;
OC Dipodidae; Allactaginae; Scarturus.
OX NCBI_TaxID=2926631 {ECO:0000313|EMBL:AEK81884.1};
RN [1] {ECO:0000313|EMBL:AEK81884.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ah {ECO:0000313|EMBL:AEK81884.1};
RX PubMed=23071573; DOI=10.1371/journal.pone.0046445;
RA Wu S., Wu W., Zhang F., Ye J., Ni X., Sun J., Edwards S.V., Meng J.,
RA Organ C.L.;
RT "Molecular and paleontological evidence for a post-cretaceous origin of
RT rodents.";
RL PLoS ONE 7:E46445-E46445(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JF938728; AEK81884.1; -; Genomic_DNA.
DR AlphaFoldDB; K4EJR1; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24248; ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR24248:SF130; ALPHA-2B ADRENERGIC RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..168
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEK81884.1"
FT NON_TER 168
FT /evidence="ECO:0000313|EMBL:AEK81884.1"
SQ SEQUENCE 168 AA; 18998 MW; 799FC29E0B5987A8 CRC64;
LFTIFGNALV ILAVMTSRSL RAPQNLFLVS LAAADILVAT LIIPFSLANE LLGYWYFRRT
WCEVYLALDV LFCTSSIVHL CAISLDRYWA VSRALEYNSK RTPRRIKCII LTVWLIAAII
SLPPLIYKGD QGPQTHERPQ CKLNQEAWYI LASSIGSFFA PCLIMILV
//
