ID K4GTK7_ANOCA Unreviewed; 224 AA.
AC K4GTK7;
DT 09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Chemokine C-X-C motif receptor 4 {ECO:0000313|EMBL:AFP56646.1};
DE Flags: Fragment;
GN Name=CXCR4 {ECO:0000313|EMBL:AFP56646.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|EMBL:AFP56646.1};
RN [1] {ECO:0000313|EMBL:AFP56646.1}
RP NUCLEOTIDE SEQUENCE.
RA Lee I.-M., Bottner-Parker K.D., Zhao Y., Bertaccini A., Davis R.E.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AFP56646.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=22993238; DOI=10.1098/rsbl.2012.0703;
RA Wiens J.J., Hutter C.R., Mulcahy D.G., Noonan B.P., Townsend T.M.,
RA Sites J.W.Jr., Reeder T.W.;
RT "Resolving the phylogeny of lizards and snakes (Squamata) with extensive
RT sampling of genes and species.";
RL Biol. Lett. 8:1043-1046(2012).
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JN702390; AFP56646.1; -; Genomic_DNA.
DR AlphaFoldDB; K4GTK7; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001277; CXCR4/ACKR2.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF594; C-X-C CHEMOKINE RECEPTOR TYPE 4; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00645; CXCCHMKINER4.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AFP56646.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..224
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFP56646.1"
FT NON_TER 224
FT /evidence="ECO:0000313|EMBL:AFP56646.1"
SQ SEQUENCE 224 AA; 25591 MW; 8B6C3C23986A7F0F CRC64;
LRSMTDKYRL HLSVADLLFV ITLPFWSVDA VISWYFGNFL CKAVHFIYTI NLYSSVLILA
FISLDRYLAI VHATNSQRPR KLLAERIVYV GVWLPALLLT VPDIIFASTS EVGGKYVCQR
FYPHETWLIS FRFQHILVGL VLPGLIILTC YCIIISKLSH SKGHQKRKAL KTTVILIVAF
FACWLPYHIG ISIDTFVLLG FIENGCTFEA ILQKWISITE ALAF
//
